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Khảo sát hiệu quả điều trị sẹo của gel thông minh nhạy nhiệt chứa liposome đóng gói curcumin

Nghiên cứu nhằm mục đích đánh giá khả năng điều trị sẹo của gel thông minh nhạy nhiệt chứa liposome đóng gói curcumin (GelTM-Lip-CUR). Đầu tiên, Lip-CUR được tổng hợp bằng phương pháp hydrate hóa màng lipid kết hợp với sóng siêu âm để giảm kích thước. | TNU Journal of Science and Technology 227 05 117 - 125 INVESTIGATION OF SCAR TREATMENT EFFECTIVENESS OF THERMAL-RESPONSIVE GEL CONTAINING CURCUMIN- ENCAPSULATED LIPOSOMES Nguyen Minh Hiep Dalat Nuclease Research Institute ARTICLE INFO ABSTRACT Received 13 02 2022 This study aims to evaluate scar treatment effectiveness of thermal-responsive gel containing curcumin-encapsulated liposome GelTM-Lip-CUR . Firstly Revised 08 4 2022 Lip-CUR was prepared using a combined method of lipid-film hydration and Published 13 4 2022 sonication. GelTM-Lip-CUR was prepared from F127 and PVA. Scar treatment effectiveness of Lip-CUR and Gel-Lip-CUR was carried out using KEYWORDS mice Mus. musculus var. Albino. The results indicated that Lip-CUR was successfully prepared with mean particle size polydispersity index zeta Curcumin potential encapsulation efficieny payload of 229.6 nm 0.245 -26.6 mV Liposome 90.2 8.1 respectively. In addition the results also showed that Lip-CUR Gel was stable under storage conditions. GelTM-Lip-CUR was liquid at a temperature of lower than 25oC and gelled at body temperature. The in vivo Scar treatment results on mice Mus. musculus var. Albino indicated that scar treatment Thermal responsive efficiency of Lip-CUR was higher than that of native CUR and achieved the highest efficiency at CUR concentration of 0.01 mg mL. Moreover GelTM- Lip-CUR exhibited a significant better scar treatment effect compared to Lip- CUR with the optimal CUR concentration of 0.05 mg mL. The results of histological analysis indicated that the tissue structure at the scar area of GelTM-Lip-CUR at a CUR concentration of 0.05 mg mL was nearly fully recovered to normal. Therefore GelTM-Lip-CUR has a great potential to be widely applied in scar treatment. KHẢO SÁT HIỆU QUẢ ĐIỀU TRỊ SẸO CỦA GEL THÔNG MINH NHẠY NHIỆT CHỨA LIPOSOME ĐÓNG GÓI CURCUMIN Nguyễn Minh Hiệp Trung tâm Công nghệ bức xạ và Công nghệ sinh học - Viện Nghiên cứu Hạt nhân THÔNG TIN BÀI BÁO TÓM TẮT Ngày nhận bài 13 .