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Đặc điểm lâm sàng, cận lâm sàng ở trẻ viêm thận Schonlein-Henoch tại Bệnh viện Nhi Trung ương

Bài viết Đặc điểm lâm sàng, cận lâm sàng ở trẻ viêm thận Schonlein-Henoch tại Bệnh viện Nhi Trung ương mô tả đặc điểm lâm sàng, cận lâm sàng và tìm hiểu một số mối liên quan ở trẻ mắc bệnh thận Schonlein Henoch tại khoa Thận - Lọc máu, Bệnh viện Nhi Trung ương. Phương pháp: Nghiên cứu mô tả cắt ngang, 42 bệnh nhi đủ tiêu chuẩn nghiên cứu từ 7/2017- 6/2020. | Journal of Pediatric Research and Practice Vol. 6 No. 2 2022 56-65 Research Paper Clinical and Subclinical Features in Henoch-Shonlein Purpura Nephritis in Children at the Vietnam National Children s Hospital Nguyen Thi Ngoc1 Le Thi Thao2 Nguyen Thu Huong1 1 Vietnam National Children s Hospital 18 879 La Thanh Dong Da Hanoi Vietnam 2 Bac Ninh Obstetric and Pediatric Hospital Huyen Quang Street Vo Cuong Ward Bac Ninh VietNam Received 3 March 2022 Revised 11 March 2022 Accepted 26 March 2022 Abstract Introduction Henoch Schonlein purpura HSP is the most common systemic vasculitis of childhood and the prognosis of kidney damage is usually severe. Objectives To describe some clinical subclinical characteristics and study some relationships in children with Henoch Schonlein purpura nephritis HSPN . Methods A cross - sectional descriptive study 42 patients with the diagnosis of HSPN at the Vietnam National Children s Hospital from 7 2017 to 6 2020. Results 29 boys 69 05 . The median age at diagnosis was 9 4 3 09. Kidney damage occured mainly in the first 3 weeks. 59 5 of children had mild renal impairment of hematuria and or proteinuria 40.5 of children had nephritic - nephrotic syndrome. The most common histopathological result was endothelial proliferation E1 accounting for 71 43 71 4 had crescents on renal biopsy mainly in persistent skin rash gastrointestinal bleeding nephritic syndrome hypertension high proteinuria.There was a linear correlation between proteinuria and crescents. Conclusions Kidney damage mainly appeared in the first 3 weeks in which nephritic - nephrotic syndrome accounted for nearly of the patients. Endothelial proliferation was the most common. Patients with persistent skin rash gastrointestinal bleeding nephrotic syndrome hypertension and high proteinuria are associated with crescents on renal biopsy. Keywords Henoch Schonlein purpra nephritis in children renal biopsy Corresponding author. E-mail address nguyenngoc20483@gmail.com https doi.org