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Pharmaceutical Substances Syntheses, Patents, Applications - Part 59

Pharmaceutical Substances Syntheses, Patents, Applications - Part 59. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Defibrotide D 581 Formulation s amp. 500 mg inj. powder 500 mg lyo. 500 mg 2 g I Trade Nameisj D Desferal Ciba F Desférai Ciba-Geigy GB Desferal Novartis I Desferal Ciba-Geigy J Desferal Novartis-Takeda USA Desferal Novartis as mesylate Defibrotide ATC B0JAX01 B06A Use antithrombotic cholinergic channel modulator stimulates fibrinolysis RN 83712-60-1 MF unspecified MW unspecified I CN defibrotide polydeoxyribonucleotides from bovine lung Extraction from mammalian organs with aqueous solution of Zn salts. Reference s DE2 154 278 Crinos appl. 3.11.1971 I-prior. 3.11.1970 . f DE 2 154 277 Crinos appl. 3.11.1971 I-prior. 3.11.1970 . I US 3 829 567 Crinos 13.8.1974 I-prior. 3.11.1970 . í US3899481 Crinos 12.8.1975 I-prior. 3.11.1970 . EP263 155 Crinos 10.4.1987 I-prior. 17.4.1986 . medical use for renal dialysis patients EP317 766 Crinos appl. 20.10.1988 I-prior. 23.10.1987 . J medical use for treatment of myocardial ischaemia í EP 152 148 Crinos appl. 11.2.1985 I-prior. 16.2.1984 . medical use for treatment of peripheral arterial disease EP 137 543 Crinos appl. 7.9.1984 I-prior. 12.9.1983 . medical use for treatment of acute renal insufficiency EP 137 542 Crinos appl. 7.9.1984 I-prior. 12.9.1983 . Formulation s vial 200 mg Trade Name s I Dasovas Carlo Erba Noravid Roussel 1986 Proci elide Crinos 1986 Deflazacort atc 1102AB13 Azacort Oxazacort Use glucocorticoid anti-inflammatory RN 14484-47-0 MF C25H3INO6 MW 441.52 EINECS 238-483-7 LD5 5200 mg kg M p.o. CN 1 lp 16P -21- acetyloxy -l l-hydroxy-2 -methyl-577-pregna-l 4-dieno 17 16-J oxazole-3 20-dione 17a-azido-3 î 16a-di-ocetoxy-5a-pregnane-11 20-dione 3 J-hydroxy-2 -methyl-5a 5 ÎH-pregnano 17 16-d oxazole-11 20 dione 1 582 D Dehydrocholic acid 2. NaBH4 3. HCI 1. semicarbozide 1. AI OCH CH4 2 4. cyclohexanone O CH3 2. Br2 3. Li2CO5 Me1 N CH3 T -0 Me H 1. aluminum triisopropoxide I I H J H 2. bromine 3. lithium II carbonate Reference s GB 1 077 393 Lepetit appl. 22.4.1965 . Nathansohn G. et al. J. Med. Chem. JMCMAR 10 .