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Pharmaceutical Substances Syntheses, Patents, Applications - Part 7

Pharmaceutical Substances Syntheses, Patents, Applications - Part 7. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Alibendol A 61 16-dehydropregnenolone 16-dehydroprogesterone 16a 17a-dihydroxy- progesterone 1 I ---------------------------- acetophenone Reference s DE 1 125 423 Olin Mathieson appl. 1959 USA-prior. 1958 . Fried J. et al. Chem. Ind. London CHINAG 1961 465. alternative synthesis . US 3 008 958 Olin Mathieson 1961 prior. 1961 . synthesis of intermediates US 2 727 909 Searle 1955 prior. 1954 . US 3 165 541 Olin Mathieson 12.1.1965 prior. 20.5.1963 . Cooley G. et al. J. Chem. Soc. JCSOA9 1955 4373. Inhoffen H.H. et al. Chem. Ber. CHBEAM 87 593 1954 . Hydorn A.E. et al. Steroids STEDAM 3 493 1964 . injection solution US 3 164 520 Olin Mathieson 5.1.1965 prior. 29.10.1962 . medical use as contraceptive GB 1 060 632 Olin Mathieson appl. 16.8.1963 USA-prior. 11.11.1962 . Formulation s cream 2 Trade Name s I Neolutin Depos. Medici Alibendol ATC C10A A03 Use antispasmodic choleretic cholekinetic RN 26750-81-2 MF C13H17NO4 MW 251.28 EINECS 247-960-9 LD50 3000 mg kg M p.o. 2000 mg kg M s.c. CN 2-hydroxy-Al- 2-hydroxyethyl -3-methoxy-5- 2-propenyl benzamide 1.Ag20 CHO ---------------- 1. silver oxide 2-hydroxy-3-methoxybenzaldehyde 2. HO CHj ethyl 2-hydroxy-3-methoxybenzoate 1-H2Ci 8r 1 K C 3 2. A ------------------ j 1. allyl bromide 62 A Alimemazine ethyl 5-allyl-2-hydroxy-3-methoxy- benzoate I ethanolamine Reference s DE 1 768 615 Roussel-Uclaf appl. 1968 F-prior. 1967 . Clemence F. et al. Chim. Ther. CHTPBA 5 188 1970 . Formulation s tabl. 100 mg Trade Name s F Cebera Irex Alimemazine Trimeprazine ATC R06AD01 Use antihistaminic psychosedative RN 84-96-8 MF C18H22N2S MW 298.45 EINECS 201-577-3 LD50 33 mg kg M i.v. 300 mg kg M p.o. 35 mg kg R i.v. 210 mg kg R p.o. CN A V ß-trimethyl-IO -phenothiazine-IO-propanamine tartrate 2 1 RN 4330-99-8 MF C18H22N2S 1 2C4H6O6 MW 746.99 EINECS 224-368-9 LDJ0 33 mg kg M i.v. 300 mg kg M p.o. 35 mg kg R i.v. 210 mg kg R p.o. ch ch3 CH3 pheno thiazine 3-dimethylomino- 2-methylpropyl chloride NaNHj sodium amide Reference s US 2 837 518 .