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Pharmaceutical Substances Syntheses, Patents, Applications - Part 38

Pharmaceutical Substances Syntheses, Patents, Applications - Part 38. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Cefaloglycin c 371 Pivacef Firma Zetacef Menarini J Cephalomax Daisan Cephazal Hokuriku Cepol Torii CEX Glaxo Ciponium Nippon Kayaku Derantel Nippon Chemiphar Garasin Wakamoto Iwalexin Iwaki Keflex Shionogi Larixin Toyama Madlexin Meiji Mamalexin Showa Mepilacin-DS Kanto Ishi Ohlexin Ohta Oracocin Tobishi Oroxin Otsuka Rinesal Kissei Salitex Banyu Segoramin Takata Sencephalin Takeda Suciralin Mohan Syncl Toyo Jozo Taicelexin Taiyo Tokiolexin Isei Xakl SS Seiyaku USA Keflex Dista 1971 Cefaloglycin ATC J01DA Cephaloglycin Use antibiotic RN 3577-01-3 MF C18H19N3O6S MW 405.43 EINECS 222-696-7 LD50 10g kg M p.o. 10g kg R P.O. CN 6R- 6a 7 3 R -3- acetyloxy methyl -7- aminophenylacetyl amino -8-oxo-5-thia-l-azabicyclo 4.2.0 oct-2-ene-2-carboxylic acid dihydrate RN 22202-75-1 MF C 8H19N3O6S 2H2O MW 441.46 COOH Hhk Cbo ----------------------------- 1. isobutyl chloroformate 2. 7-aminocephalosporanic acid COOH 0 N-Cbo-cefaloglycin I N-Cbo-D-phenyl-glycine Reference s GB 985 747 Eli Lilly appl. 22.8.1962 USA-prior. 11.9.1961 . US 3 497 505 Eli Lilly 24.2.1970 appl. 24.10.1966 . GB 1 017 624 Merck Co. appl. 10.1.1963 USA-prior. 16.1.1962 . acylation via silyl-dcrivatives DOS 1 942 454 Lilly appl. 20.8.1969 USA-prior. 23.8.1968 . microbiological acylation US 4 073 687 Shionogi 14.2.1978 J-prior. 14.5.1975 . Formulationfs cps. 250 mg 500 mg 372 c Cefaloridine Trade Name s J Kefglycin Shionogi USA Kafocin Lilly wfm Cefaloridine ATC J01DA02 Cephaloridine Use antibiotic RN 50-59-9 MF C19H17N3O4S2 MW 415.49 EINECS 200-052-6 LD50 2200 mg kg M Í.V. 20 g kg M p.o. 1065 mg kg R Í.V. 2500 mg kg R p.o. CN 6R-trans -l- 2-carboxy-8-oxo-7- 2-thienylacetyl amino -5-thia-l-azabicyclo 4.2.0 oct-2-en-3-yl methyl pyridinium hydroxide inner salt pH 6 5 cefolotin pyridine Cefoloridine Referenced GB 1 030 630 Glaxo appl. 14.12.1962 . DE 1 445 828 Glaxo appl. 14.12.1963 GB-prior. 14.12.1962 2.12.1963 . FR 1 384 197 Glaxo appl. 13.12.1963 GB-prior. 14 12.1962 2.12.1963 . DAS 1 670 599 Lilly appl. .