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Pharmaceutical Substances Syntheses, Patents, Applications - Part 41

Pharmaceutical Substances Syntheses, Patents, Applications - Part 41. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Ceftazidime c 401 0 0 H-iCzil 0 CH3 ethyl acetoacetote NaN02 CH3C00H ------------- OH ethyl 2-hydroxy-iminoacetoocetate so2ci2 ch2ci2 ---------------- sulfuryl chloride ethyl 4-chloro-2- hydroxyimino- ocetoacetote I nh2 s nh2 dimethylaniline ---------------- trityl chloride thioureo thiazol-4-yl -2-hydroxy- iminoacetote ethyl Z -2-hydroxyimino-2- 2-tritylaminothiozol-4-yl acetate II 0 X H3C4-CH3 CH3 tert-butyl ethyl Z -2- 1 -tert-butoxy- 2-bromo-2- carbonyl-1 -methylethoxyimino - methyl- 2- 2-tritylaminothiozol-4- propionate yl ocetote III 1. CH3OH NaOH 2. HCI III ----------------------- 0 h3c-I-ch3 0 0 h3c- -ch3 cn3 Z -2- 1 -tert-butaxycarbanyl-1 -methylethoxyimino -2- 2-tritylaminothiazol-4-yl -ocetic acid TV 402 c Ceftazidime coo- cefaloridine q. V. CH3 1. CH2CI2 Vr ch3 CISi CH3 3 30-35 C 2. -20 C PCI5 3. CH2CI2 1 3-butonediol ---------------------------- COOH Cl- 7 R -amino-3- 1 -pyridiniomethyl -3-cephem-4-carboxylic acid chloride monohydrochloride V 1. V CH-jCON CH-j 2 ch3cn N C2H5 3 -10 C 2. CH OH ---- ------------------------- VI Reference s DOS 2 921 316 Glaxo appl. 25.5.1979 GB-prior. 26.5.1978 . US 4 258 041 Glaxo 24.3.1981 GB-prior. 26.5.1978 . GB 2 025 398 Glaxo appl. 25.5.1979 GB prior. 26.5.1978 . US 4 525 587 Eli Lilly 25.6.1985 prior. 27.12.1982 3.2.1984 . intermediate IV US 4 497 956 Glaxo 5.2.1985 GB-prior. 13.11.1981 . acid chloride of IV EP 101 148 Glaxo appl. 28.4.1983 GB-prior. 29.4.1982 . intermediate V EP 135 258 Eli Lilly appl. 18.6.1984 USA-prior. 20.6.1983 . EP 70 706 Glaxo appl. 16.7.1982 GB-prior. 17.7.1981 . salts and crystal modifications crystalline dihydrochloride US 4 467 086 Glaxo 21.8.1984 GB-prior. 2.10.1979 . Ceftezole c 403 pentahydrate DOS 3 037 102 Glaxo appl. 1.10.1980 GB-prior. 2.10.1979 . GB2063 871 Glaxo appl. 1.10.1980 GB-prior. 2.10.1979 . US4329453 Glaxo 11.5.1982 appl. 9.9.1980 GB-prior. 2.10.1979 . sesquihydrate DOS 3 313 816 Hoechst appl. 16.4.1983 . EP 122 584 Hoechst appl. 10.4.1984 D-prior. 16.4.1983 . .