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Pharmaceutical Substances Syntheses, Patents, Applications - Part 48

Pharmaceutical Substances Syntheses, Patents, Applications - Part 48. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Cimetidine C 471 Reference s DOS 2 934 747 Otsuka appl. 28.8.1979 J-prior. 1.9.1978 . US 4 277 479 Otsuka 7.7.1981 J-prior. 1.9.1978 . Nishi.T.etal. Chem. Pharm. Bull. CPBTAL 31 1151 1983 . medical use for treatment of nephritis JP2 178 227 Otsuka appl. 28.12.1988 . medical use for treatment of Raynaud s syndrome JP 2 178 226 Otsuka appl. 28.12.1988 . Formulation s tabl. 50 mg 100 mg Trade Namets J Pletaal Otsuka Retal Otsuka 1988 Cimetidine ATC A02BA01 Use peptic ulcer therapeutic H2-receptor antagonist RN 51481-61-9 MF C10H16N6S MW 252.35 EINECS 257-232-2 LD50 150 mg kg M i.v. 2550 mg kg M p.o. 106 mg kg R i.v. 5 g kg R p.o. 206 mg kg dog i.v. 2600 mg kg dog p.o. CN lV-cyano-W-methyl-7V - 2- 5-methyl-l 77-imidazol-4-yl methyl thio ethyl guanidine ethyl 2-chloro-ocetoocetate H N CHO Cl 2 0 Na liq. NH- ethyl 5-methyl-imidazole-4- o IjC-2 o HCI formamide carboxylate HO- 4- hydroxymethyl- 5- methylimidazole hydrochloride I H H C XN. 2HCI cysteamine hydrochloride 4- 2-aminoethylthio - methyl -5-methyl- imidozole dihydrochlaride CN H3C A xCH3 --------- ------------ II dimethyl cyano-carboimidodithioate from cyanamide KOH carbon disulfide and dimethyl sulfate Reference s US 3 894 151 Smith Kline French 8.7.1975 GB-prior. 20.4.1972 . US4000 302 Smith Kline French 28.12.1976 GB-prior. 20.4.1972 . DOS 2 320 131 Smith Kline French appl. 19.4.1973 GB-prior. 20.4.1972 - medical use. DOS 2344 779 Smith Kline French appl. 5.9.1973 GB-prior. 5.9.1972 and 8.2.1973 . US 3 950 333 Smith Kline French 13.4.1976 appl. 14.3.1974 prior. 29.2.1972 and 20.9.1972 . 472 C Cimetropium bromide cimetidine A DOS 2 742 531 Smith Kline French appl. 21.9.1977 GB-prior. 21.9.1976 24.1.1977 . GB 1 543 238 Smith Kline French appl. 21.9.1976 24.1.1977 20.9.1977 valid from 13.12.1977 . precursors and alternative methods DOS 2 637 670 Smith Kline French appl. 20.8.1976 USA-prior. 20.8.1975 and 27.5.1976 . FR 2 321 490 Smith Kline French appl. 16.8.1976 USA-prior. 20.8.1975 and 27.5.1976 . GB 1 338 169 .