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Pharmaceutical Substances Syntheses, Patents, Applications - Part 53

Pharmaceutical Substances Syntheses, Patents, Applications - Part 53. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Clomocycline c 521 phosgene 3-chloro-10 11 -di-hydro-5H-dibenz- b f ozepine I 160-210 C ---- ỹH3 ch3 --------------- II 3-dimethylamino- 1 -propanol 1 NaNH2 2. cpH3 CH3 1 ---------- ------ 1. sodium amide 2. 3-dimethylamino-propyl chloride Clomipramine Reference s US 3 515 785 Geigy 2.6.1970 CH-prior. 6.12.1958 12.1.1959 . DE 1 161 278 Geigy appl. 5.12.1959 CH-prior. 6.12.1958 12.1.1959 . CH 371 799 Geigy appl. 6.12.1958 . Craig P.N. et al. J. Org. Chem. JOCEAH 26 135 1961 . starting material DE 1 166 200 Geigy appl. 1959 CH-prior. 1958 1959 . US 3 056 774 Geigy 1962 CH-prior. 1958 . US 3 056 776 Geigy 1962 CH-prior. 1959 . Formulation s amp. 25 mg 2 ml drg. 25 mg f. c. tabl. 10 mg 25 mg s. r. tabl. 75 mg Trade Name s D Anafranil Novartis F Anafranil Novartis J Anafranil Fujisawa Hydiphen ASTA Medica GB Anafranil Novartis USA Anafranil Novartis as AWD I Anafranil Geigy hydrochloride Clomocycline Chlormethylencycline Clomociclina ATC J01AA11 Use antibiotic RN 1181-54-0 MF C23H25C1N2O9 MW 508.91 LDS0 115 mg kg M i.v. 2830 mg kg M p.o. CN 4S- 4a 4aa 5aa 6ß 12aoc -7-chloro-4- dimethylamino -1 4 4a 5 5a 6 11 12a-octahydro-3 6 10 12 12a- pentahydroxy-A- hydroxymethyl -6-methyl-1 11 -dioxo-2-naphthacenecarboxamide sodium salt RN 68-20-2 MF CjaH ClN aO MW 530.89 522 C Clonazepam chlortetracycline formhydrochloride aldehyde q. v. Reference s BE 628 142 Leo Ind. Chim. Farm. S.p.A. appl. 7.2.1963 . Formulation s cps. 170 mg as sodium salt Trade Name s GB Megaclor Pharmax wfm I Megaclor Pharmax wfm Clonazepam ATC N03AE01 Use anticonvulsant RN 1622-61-3 MF C15H 0ClN3O3 MW 315.72 EINECS 216-596-2 CN 5- 2-chlorophenyl -1 3-dihydro-7-nitro-2 7-1 4-benzodiazepin-2-one 2-chloro-2 -nitrobenzo-phenone H2. Raney-Ni ------------- 2-amino-2 -chlorobenzo-phenone bromoacetyl 1 liq. NH pyridine phenyl -2 oxo 5- 2-chlora- 2 3-dihydro- 1H- 1 4-benzo- diozepine Reference s Sternbach L.H. et al. J. Med. Chem. JMCMAR 6 261 1963 . US 3 116203 Hoffmann-La Roche 31.12.1963 prior. 14.3.1962 . US 3 .