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Pharmaceutical Substances Syntheses, Patents, Applications - Part 100

Pharmaceutical Substances Syntheses, Patents, Applications - Part 100. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Gusperimus trihydrochloride G 991 2. Pd-C NiCI2 NaBH4 3. HCI X ---------------------------------- 1. dicyclohexylcarbodiimide 0 NH 7-guanidinoheptanamide hydrochloride XI final product 1. HOOC COOH H20 60 C 2. chromatography an sephodex LH-20 XI V -------------------- 1. glutaric acid H OH 0 NH H o H H 2 O 3 HCI Gusperimus trihydrochloride Refere.nce s DE 3 626 306 Microbiochemical Research Found. appl. 11.2.1988 D-prior. 2.8.1986 . BE 894 651 Microbiochemical Research Found. appl. 31.1.1983 J-prior. 8.10.1981 . JP 08 020 533 Nippon Kayaku appl. 23.1.1996 J-prior. 7.7.1994 . DE 3 506 330 Takara Skuzo Co. Nippon Kayaku Co. appl. 29.8.1985 J-prior. 29.2.1984 . purification JP 59 029 652 Nippon Kayaku Co. appl. 16.2.1984 J-prior. 10.8.1982 . pharmaceutical preparations JP02009 816 Nippon Kayaku Co. Takara Skuzo Co. appl. 12.1.1990 J-prior. 29.6.1988 . EP 188 821 Microbial Chemistry Research Found. appl. 30.7.1986 J-prior. 14.1.1985 . use of gusperimus hydrochloride CA 2 142 376 Bristol-Myers Squibb Co. appl. 26.8.1995 USA-prior. 25.2.1994 . WO9 405 323 Jekus Hopkins Univ. School of Medicine appl. 17.3.1994 WO-prior. 4.9.1982 . DE 3 626 306 Behringwerke A.G. appl. 11.2.1988 D-prior. 2.8.1986 . synthesis of 0-tert-butyl S - 4 6-dimethyl-2 pyrimidinyl thiocarbonate and O-benzyl 5- 4 6-dimethyl-2- pyrimidinyl thiocarbonate Nagasawaetal. Bull. Chem. Soc. Jpn. BCSJA8 46 1269 1271 1973 . DE 2 245 392 Nitto Boseki appl. 12.4.1973 J-prior. 17.9.1971 27.9.1971 30.9.1971 10.1.1972 . US 3 936 452 Nitto Boseki appl. 3.2.1976 J-prior. 8.9.1972 . Formulation s vial inj. 100 mg as trihydrochloride Trade Name s J Spanidin Nippon Kayaku 992 H Halazone Halazone Aseptamide ATC D08A Use antiseptic chemotherapeutic RN 80-13-7 MF C7H5C12NO4S MW 270.09 EINECS 201-253-1 CN 4- dichloroamino sulfonyl benzoic acid sodium salt RN 5698-56-6 MF C7H4Cl2NNaO4S MW 292.07 EINECS 227-176-3 COOH 0 s o I nh2 4-sulfamoyl-benzoic ocid COOH 0 S 0 I cK ci Halozone Reference s DE 318 899 M. Claass appl. 1918 .