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Pharmaceutical Substances Syntheses, Patents, Applications - Part 124

Pharmaceutical Substances Syntheses, Patents, Applications - Part 124. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Mefruside M 1231 pyridine-2-carboxoldehyde a-2-pyridyl-2 8-bis trifluoromethyl -4-quinolinemethanol H2 PtO ---------- Mefloquine OH HO CCIj NH2OH HCI ------------ hydroxylamine hydrochloride H2SO4 ------- chloral hydrate isatin VI i i p pr NaOH VI 3 Y 3 -------- IV o 1 1 1 -trifluoro- acetone 2. BrMg ---------------------k y 2. 2-pyridylmagnesium Reference s a Ohnmacht C.J. et al. J. Med. Chem. JMCMAR 14 926 1971 . b DOS 2 806 909 Roche appl. 17.2.1978 USA-prior. 17.2.1977 . c DOS 2 940 443 BASF appl. 5.10.1979 . alternative synthesis EP 103 259 Roche appl. 6.9.1983 CH-prior. 10.9.1982 . preparation of pure mefloquine hydrochloride US 4 507 482 Roche 26.3.1985 CH-prior. 14.4.1982 . EP 92 185 Roche appl. 14.4.1983 CH-prior. 14.4.1982 . hydrochloride modification E EP 137 375 Roche appl. 20.9.1984 CH-prior. 7.10.1983 . Formulation s tabl. 250 mg as hydrochloride Mefloquine Trade Name s D Lariam Roche F Lariam Roche as hydrochloride GB Lariam Roche I Lariam Roche USA Lariam Roche Mefruside ATC C03BA05 Use diuretic RN 7195-27-9 MF C13H19C1N2O5S2 MW 382.89 EINECS 230-562-4 LD50 500 mg kg M i.v. 10 g kg M p.o. 500 mg kg R i.v. 10 g kg R p.o. 5 g kg dog p.o. CN 4-chloro-7V1-methyl-7V1- tetrahydro-2-methyl-2-furanyl methyl -l 3-benzenedisulfonamide 1232 M Megestrol acetate H2 Roney-Ni 2-cyano-2-methyl-tetrohydro-furan 2-aminomethyl- 2-methyltetra-hydrafuron l_i x0 HjC X0- CH3 ----------------------k dimethyl sulfate 2-methy -2- methylamino-methyl tetra-hydrofuran I o s o I nh2 3-sulfamayl-4-chlorobenzenesulfonyl chloride Reference s GB 1 031 916 Bayer appl. 30.11.1964 D-prior. 30.11.1963 . Formulation s tabl. 25 mg Trade Name s D Baycaron Bayer Vital Bendigon Bayer Vital -comb. Caprinol Bayer -comb. wfm Duranifin Sali durachemie -comb. Sali-Adalat Bayer Vital -comb. Sali-Prent Bayer Vital -comb. Sali-Presinol Bayer -comb. Thomaeamin Thomae -comb. wfm F Tensid Bayer Pharma - comb. wfm GB Baycaron Bayer I Baycaron Bayer wfm Mefrusal Bayropharm wfm Rexitene Plus LPB -comb. .