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Pharmaceutical Substances Syntheses, Patents, Applications - Part 135

Pharmaceutical Substances Syntheses, Patents, Applications - Part 135. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Minocycline M 1341 Minocycline ATC J01AA08 Use antibiotic RN 10118-90-8 MF C23H27N3O7 MW 457.48 LDS0 140 rng kg M i.v. 3100 mg kg M p.o. CN 4S- 4a 4aa 5aa 12aa -4 7-bis dimethylarnino -l 4 4a 5 5a 6 l l 12a-octahydro-3 10 12 12a-tetrahydroxy-1 11 -dioxo-2-naphthacenecarboxamide monohydrochloride RN 13614-98-7 MF C23H27N3O7 HCl MW 493.94 EINECS 237-099-7 LDS0 154 mg kg M i.v. 3600 mg kg M p.o. 164 mg kg R i.v. 2380 mg kg R p.o. 6-demethyltetrocycline KNOj liq. HF -------------- 1 in Reference s US 3 148 212 American Cyanamid 8.9.1964 appl. 22.12.1961 . US 3 226 436 American Cyanamid 28.12.1965 prior. 24.10.1961 22.12.1961 17.5.1963 . US 3 345 410 American Cyanamid 3.10.1967 prior. 14.3.1966 1.12.1966 . Church R.F.R. et al. J. Org. Chem. JOCEAH 36 723 1971 . DE 1 245 942 American Cyanamid appl. 15.5.1962 USA-prior. 21.10.1961 22.12.1961 7.2.1962 . DE 1 643 767 American Cyanamid prior. 16.1.1968 . intermediates US 3 403 179 American Cyanamid 24.9.1968 prior. 10.1.1967 . US 3 483 251 American Cyanamid 9.12.1969 prior. 3.3.1967 . 1342 M Minoxidil purification DOS 2 309 582 American Cyanamid appl. 26.2.1973 USA-prior. 11.5.1972 . Formulations cps. 50 mg 100 mg f. c. tabl. 50 mg 100 mg susp. 50 mg 60 ml oral vial 100 mg as hydrochloride Trade Name s D Aknin Sanofi Winthrop Zacnan Lipha Santé J Minomycin Lederle- F Klinomycin Lederle 1972 generics Acneline Wyeth-Lederle Minolis Noviderm Mynocine Wyeth-Lederle GB I Aknemin Merck Sharp Dohme -comb. Dentomycin Wyeth Minocin Wyeth 1973 -comb. Minocin Cyanamid 1972 USA Takeda Dynacin Medicis Minocin Lederle 1971 Vectrin Warner Chilcott 1973 1973 Minoxidil ATC C02DC01 Dl 1AX01 Use antihypertensive RN 38304-91-5 MF C9HI5N5O MW 209.25 EINECS 253-874-2 LD50 51 mg kg M i.v. 1 g kg M p.o. 49 mg kg R i.v. 1321 mg kg R p.o. CN 6- 1 -piperidinyl -2 4-pyrimidinediamine 3-oxide barbituric acid PÛCIj 2 4 6-trichloro-pyrimidine 6-chloro- 2 4-diamino-pyrimidine 2.4-dichloro-phenol 2 4-diamino-6- 2 4-dichlorophenoxy -pyrimidine I .