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Pharmaceutical Substances Syntheses, Patents, Applications - Part 136

Pharmaceutical Substances Syntheses, Patents, Applications - Part 136. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Moclobemide M 1351 Isolation from cultures of Eupenicillium hrefeldianum NRRL 5734. a Amberlite IRA-411 pH 10. b Chromatography on DEAE-Sephadex A-25. -nh2 HO i N OH OH OH Mizoribine Reference s BE 799 805 Toyo Jozo appl. 31.11.1973 J-prior. 21.5.1973 . DOS 2 326 916 Toyo Jozo appl. 23.5.1973 J-prior. 21.5.1973 . Mizuno K. et al. J. Antibiot. JANTAJ 27 775 1974 . controlled-release formulation JP59 227 817 Toyo Jozo appl. 7.6.1983 . Formulation s f. c. tabl. 10 mg tabl. 10 mg Trade Name s J Bredinin Toyo Jozo Moclobemide ATC- NO6AGO2 Ro-11-1163 Use antidepressant reversible nonhydrazide MAO-A-inhibitor antiparkinsonian RN 71320-77-9 MF CBH17C1N2O2 MW 268.74 LD5 707 mg kg R p.o. CN 4-chloro-A - 2- 4-morpholinyl ethyl benzamide N- 2-ominoethyl -morpholine I pyridine Moclobemide 1352 M Modafinil Reference s DE 2 706 179 Hoffmann-La Roche appl. 14.2.1977 A-prior. 16.2.1976 . GB 1 512 194 Hoffmann-La Roche appl. 24.5.1978 A-prior. 16.2.1976 2.9.1976 20.4.1977 17.2.1976 4.6.1976 . medical use for treatment of cognitive disorders US 4 906 626 Hoffmann-La Roche 6.3.1990 appl. 13.1.1989 CH-prior. 8.12.1988 . Fomulation s f. c. tab . 150 mg 300 mg tabl. 100 mg 150 mg 300 mg Trade Name s D Aurorix Roche F Moclamine Produits GB Manerix Roche Roche Aurorix Roche Modafinil CRL-40476 ATC N06BA07 Use psychostimulant -adrenoceptor agonist treatment of narcolepsy and idiopathic hypersomnia RN 68693 11-8 MF C15Hl5NO2S MW 273.36 CN 2- diphenylmethyl sulfinyl acetamide racemate RN 112111-49-6 -form MF CJ5H15NO2S MW 273.36 RN 112111-47-4 - -form MF C15H15NO2S MW 273.36 RN 112111-43-0 MF C15HI5NO2S MW 273.36 benzhydrol HBr 95 C 2- diphenylmethyl-thio acetic acid I 1. SOCI 2. aq. NH3 3. H2O2 Modafinil 1. H2O2 2. CH3 2SO4 NaHCOj 3. aq. NH-j Modafinil Moexipril M 1353 Reference s DE 2 809 625 Laboratoire L. Lafon appl. 5.10.1978 GB-prior. 31.3.1977 . EP 233 106 Laboratoire L. Lafon appl. 19.8.1987 F-prior. 31.1.1986 . use o modafinil as neuroprotective agent EP 462 004 Laboratoire L. Lafon