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Pharmaceutical Substances Syntheses, Patents, Applications - Part 140

Pharmaceutical Substances Syntheses, Patents, Applications - Part 140. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Nalorphine N 1391 monohydrochloride RN 58895-64-0 MF C21H25NO3 HCI MW 375.90 -base RN 131378-67-1 MF C21H25NO3 MW 339.44 -monohydrochloride RN 131712-55-5 MF C2 H25NO3 HCl MW 375.90 Reference s Hahn F.E. et al. J. Med. Chem. JMCMAR 18 259 1975 . synthesis ỡ nalmefene from naltrexone US 7 421 900 Nat. Inst of Health appl. 28.8.1990 USA-prior. 26.10.1989 . US 4 322 426 Du Pont de N. appl. 30.3.1982 USA-prior. 28.4.1980 . US 4 751 307 Mallinckrodt Inc. appl. 27.2.1987 USA-prior. 17.1.1985 . EP 140 367 Key Pharm. Inc. appl. 8.5.1985 USA-prior. 1.11.1983 . use öfnalmefene US 4 880 813 Baker Cummins Pharm. appl. 14.11.1989 USA-prior. 22.7.1988 . WO 8 910 125 Baker Cummins Pharm. appl. 2.11.1989 USA-prior. 27.4.1988 . WO 8 702 586 Key Pharmaceuticals appl. 7.5.1987 29.1.1985 . US 4 639 455 Key Pharmaceuticals appl. 27.1.1987 USA-prior. 2.1.1984 . US 4 863 928 Baker Cummins Pharm. appl. 5.9.1989 USA-prior. 4.1.1989 . US 4 877 791 Baker Cummins Pharm. appl. 31.10.1989 USA-prior. 1.11.1988 . US4923 875 Baker Cummins Pharm. appl. 8.5.1990 10.7.1989 . WO 9 218 126 Baker Cummins Pharm. appl. 29.10.1992 USA-prior. 10.4.1991 . WO 9 118 605 Finland appl. 12.12.1991 USA-prior. 4.6.1990 . formulation US 4 511 570 Key Pharmaceuticals appl. 16.4.1985 28.3.1983 . combination WO9 531 985 Italy appl. 30.11.1995 1-prior. 24.5.1994 . Formulation s amp. 100 lg ml 2 mg 2 ml syringe 2 mg 2 ml as hydrochloride Trade Name s USA Revex Ohmeda Nalorphine ATC V03AB02 Use morphine antagonist RN 62-67-9 MF C19H21NO3 MW 311.38 EINECS 200-546-1 LD5I 127 mg kg M Í.V. 1140 mg kg M p.o. 226 mg kg R i.v. CN 5a 6a -7 8-didehydro-4 5-epoxy-17- 2-propenyl morphinan-3 6-diol 1392 N Naloxone hydrochloride RN 57-29-4 MF CI9H21NO3 HCl MW 347.84 EINECS 200-321-8 LD . 63 mg kg M Í.V. 1150 mg kg R p.o. 120 mg kg dog i.v. hydrobromide RN 1041-90-3 MF C19H21NO3 HBr MW 392.29 EINECS 213-868-2 LD5l 260 mg kg M i.p. 921 mg kg M s.c. morphine O 0 0 CH diamorphine BrCN I cyanogen bromide Reference s US 2 364 833 Merck Co.