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Pharmaceutical Substances Syntheses, Patents, Applications - Part 144

Pharmaceutical Substances Syntheses, Patents, Applications - Part 144. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Nicotinamide N 1431 Reference s DE 839 036 Ciba appl. 1948 CH-prior. 1947 . US 2 485 152 Ciba 1949 CH-prior. 1947 . Formulation s tabl. 5 mg 10 mg Trade Name s F Trafuril Ciba wfm I Balsamo Di Trasalen Ciba -comb. wfm Trafuril Ciba wfm Nicotinamide Niacinamide ATC A11HA01 Use vitamin B3 antipellagra agent RN 98-92-0 MF C6H6N2O MW 122.13 EINECS 202-713-4 LDJ 1.68 g kg R s.c. CN 3-pyridinecarboxamide Öl - tooh NHj 200 C -------------- nicotinic acid nicotinonitrile H20 NaOH or CaC03 Nicotinamide Reference s a US 2 280 040 SMA Corp. 1942 appl. 1939 . US 2 314 843 American Cyanamid 1943 appl. 1941 . US 2 993 051 Cowles Chem. Comp. 18.7.1961 appl. 26.2.1958 . b US 2 904 552 Distillers 15.9.1959 appl. 21.7.1958 . DAS 2 539 435 Showa Denko appl. 4.9.1975 J-prior. 11.9.1974 . Formulation s amp. 100 mg tabl. 200 mg Trade Name s D Nicobion Merck numerous combination preparations F Nicobion 500 Astra further combination preparations GB Papulex Euroderma generic and combination preparations I Eparolo Bonomelli -comb. Farmobion Pp Farmochimica Ital. letepar Rottapharm -comb. Nicospasmolo Italfarmaco -comb. Nicotinamide Dynacren Nicotinamide IDI Vitabil composto 1BP -comb. Vit. PP Angelini generic and polyvitaminous combination preparations J numerous generic and combination preparations USA Mega-B Arco -comb. 1432 N Nicotinic acid Nicotinic acid ATC auhaoi Acide nicotinique Acidum nicotinicum Niacin Use vasodilator peripheral antipellagra effect antihyperlipidemic RN 59-67-6 MF C6H5NO2 MW 123.11 EINECS 200-441-0 LDW 5 g kg M i.v. 3720 mg kg M p.o. 7 g kg R p.o. CN 3-pyridinecarboxylic acid magnesium salt RN 7069-06-9 MF C12H8MgN2O4 MW 268.51 EINECS 230-361-1 LD 9 g kg M p.o. sodium salt RN 54-86-4 MF C6H4NNaO2 MW 145.09 EINECS 200-215-1 LD50 2900 mg kg M i.v. HjC O CHj v ch3 NH3 220-280 C. 100 bar ---------------------- HNO-J TOOH paraldehyde 5-ethyl-2-methyl-pyridine Nicotinic acid Reference s DOS 2 046 556 Lonza appl. 22.9.1970 CH-prior. 24.9.1969 . US 2 905 688 Abbott 1959 .