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Pharmaceutical Substances Syntheses, Patents, Applications - Part 146

Pharmaceutical Substances Syntheses, Patents, Applications - Part 146. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Nitrefazole N 1451 HCl Ill - 2-amino-5- nitrobenzo- phenone Nitrazepam Reference s US 3 109 843 Hoffmann-La Roche 5.11.1963 appl. 21.6.1962 prior. 28.7.1961 4.12.1961 . US 3 116 203 Hoffman-La Roche 31.12.1963 prior. 14.3.1962 . US 3 123 529 Hoffman-La Roche 3.3.1964 prior. 9.3.1962 . DE 1 136 709 Hoffman-La Roche appl. 7.12.1960 USA-prior. 10.12.1959 27.6.1960 . DE 1 145 626 Hoffman-La Roche appl. 7.12.1960 USA-prior. 10.12.1959 15.1.1960 26.4.1960 27.6.1960 . Sternbach L.H. et al. J. Med. Chem. JMCMAR 6 261 1963 . DAS 1 811 785 Delmar Chemicals appl. 29.11.1968 CDN-prior. 29.11.1967 . condensation o 2-aminobenzophenone with glycine and POCl3 nitrobenzene and following nitration with KNO H2SO4 DOS 2 252 378 Roche appl. 25.10.1972 CH-prior. 18.11.1971 . Formulation s drops 0.5 g 100 g tabl. 5 mg 10 mg Trade Name s D Dormalon Pharma Novanox -forte Pfleger generics Wernigerode Radedorm ASTA Medica 1 Mogadon Roche Dormo-Puren Isis Puren AWD J Benzalin Shionogi Eatan N Desitin F. Mogadon Roche Nelbon Sankyo Imeson Desitin Rohypnol Roche USA Mogadon Roche wfm Mogadan Roche Roche GB Mogadon Roche Nitrefazole ATC V03AA Use alcohol deterrent RN 21721-92-6 MF C10H8N4O4 MW 248.20 EINECS 244-542-8 LD50 5.501 g kg M p.o. 4.813 g kg R p.o. 6.4 g kg dog p.o. CN 2-methyl-4-nitro-l- 4-nitrophenyl -17 -imidazole Na 2-methyl-4-nitro-imidozol sodium salt 1 -fluoro-4-nitrobenzene Reference s DE 1 620 043 Merck AG appl. 15.10.1966 . DOS 2 145 651 Merck AG appl. 13.9.1971 . 1452 N Nitrendipine medical use DOS 2 645 709 Merck AG appl. 9.10.1976 . Formulation s cps. 0.2 g Trade Name s D Altimol Merck wfm Nitrendipine atc coscaos Use calcium antagonist antihypertensive RN 39562-70-4 MF C18H20N2O6 MW 360.37 EINECS 254-513-1 LD50 34.5 mg kg M i.v. 2540 mg kg M p.o. 12.6 mg kg R i.v. 15.37 g kg R p.o. 2.5 mg kg dog i.v. 100 mg kg dog p.o. CN 1 4-dihydro-2 6-dimethyl-4- 3-nitrophenyl -3 5-pyridinedicarboxylic acid ethyl methyl ester HCI ethyl acetoacetote 3-nitro- ethyl 3-nitro- benzoldehyde .