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Pharmaceutical Substances Syntheses, Patents, Applications - Part 162

Pharmaceutical Substances Syntheses, Patents, Applications - Part 162. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Phenglutarimidc P 1611 2-phenylbutyric cid soci2 thionyl chloride 0 o u H2NZT4H. ureo Pheneturide 0 0 Reference s DRP249 241 Bayer 1910 . Kushner S. el al. J. Org. Chem. JOCEAH 16 1283 1951 . optical active isomers CH 374 644 Lab. Sapos appl. 30.10.1958 . Trade Name s F Trinuride Robert et I Carrière -comb. wfm Lircapil Lirca -comb. wfm GB Benuride Bengue wfm J Sepotence Pulv. Kanto generic Phenglutarimide ATC N04AA09 Use antiparkinsonian RN 1156-05-4 MF MW 288.39 EINECS 214-587-8 LD50 1200 mg kg M p.o. CN 3- 2- diethylamino ethy1 -3-phenyl-2 6-piperidinedione monohydrochloride RN 1674-96-0 MF CI7H24N2O2 HC1 MW 324.85 EINECS 216-819-3 LD50 1200 mg kg M p.o. benzyl cyanide r-CH z N Cl-7 ch3 2-diethylamino ethyl chloride NaNH2 sodium amide 4-diethylamino-2-phenyl- butyronitrile 1 o ch2 ammonium hydroxide H5C6 CH2-N CH3 -j OH-----------------------k benzyltrimethyl- 4-diethylamino-2- 2-methoxycarbonylethyl -2-phenylbutyronitrile II acrylic acid methyl ester 1. KOH 2. CHjCOOH H2SO 1612 P Phenindamine Reference s US 2 664 424 Ciba 1953 CH-prior. 1950 . Trade Name s D Aturbal Ciba wfm GB Aturbane Ciba wfm Phenindamine ATC R06AX04 Use antiallergic antihistaminic RN 82-88-2 MF C19H19N MW 261.37 EINECS 201-443-4 LD5o 265 mg kg M p.o. CN 2 3 4 9-tetrahydro-2-methy 1-9-phenyl- l -indeno 2 1 -c pyridine tartrate 1 1 RN 569-59-5 MF CJ9H19N C4H6O6 MW 411.45 EINECS 209-320-7 LD50 18 mg kg M i.v. 265 mg kg M p.o. 280 mg kg R p.o. ß ß - methylimino b ts- propiaphenone aceto- methyl- form- phenone omine aldehyde 3-benzoyl-4-hydroxy- 1 -methyl-4-phenyl-piperidine 1 cone. HBr I --------------- 2-methyl-9-phenyl- 2 3-dihydro-1 H- indeno 2 1 -c pyridine H2 . Roney-Ni -------------- Reference s US 2 470 108 Roche 1949 appl. 1947 . Fonnulation s tabl. 25 mg as tartrate Trade Name s D Fluprim Roche -comb. wfm GB Thephorin Sinclair USA Nolahist Camrick Nolamine Carnrick Pheniramine ATC R06AB05 Use antihistaminic RN 86-21-5 MF C16H20N2 MW 240.35 EINECS 201-656-2 LD5o 48 mg kg M i.v. CN .