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Pharmaceutical Substances Syntheses, Patents, Applications - Part 176

Pharmaceutical Substances Syntheses, Patents, Applications - Part 176. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers. | Pyrantel P 1751 Trade Name s F Norbiline Bellon -comb. I Norbiline Rhône-Poulenc Rorer Pyrantel ATC P02CC01 Use anthelmintic nematodes RN 15686-83-6 MF CnH14N2S MW 206.31 EINECS 239-774-1 LD 0 175 mg kg M p.o. 170 mg kg R p.o. 2 g kg dog P.O. CN E -1 4 5 6-tetrahy dro-1 -methy 1-2- 2- 2-thieny l etheny l pyrimidine tartrate 1 1 RN 33401-94-4 MF CnH14N2S C4H6O6 MW 356.40 E1NECS 251-501-8 LD50 2220 pg kg M Í.V. 123 mg kg M p.o. 170 mg kg R p.o. pamoate 1 1 RN 22204-24-6 MF CnH14N2S C23H16O6 MW 594.69 EINECS 244-837-1 LD5 620 mg kg M i.p. 535 mg kg R i.p. NC TOOH CHjC00NH4 pyridine 3- 2-thienyl -acrylonitrile thiophene-2- cyonoocetic carboxaldehyde acid nh2 3- 2-thienyl acrylamide I propane sultone nh2 N-methyltri-methylenediamine Reference s BE658987 Pfizer appl. 28.1.1965 GB-prior. 28.1.1964 13.8.1964 26.9.1964 . US 3 502 661 Pfizer 24.3.1970 prior. 14.2.1967 5.6.1967 9.11.1967 . CH 404 677 Dr. A. Wander appl. 2.12.1960 . CH 398 620 Dr. A. Wander appl. 16.8.1960 . GB 980 853 Dr A. Wander appl. 16.8.1961 CH-prior. 16.8.1960 2.12.1960 . NL 147 426 Dr. A. Wander appl. 24.5.1963 CH-prior. 25.5.1962 8.6.1962 5.12.1962 15.2.1963 . DE 1 280 879 Wander appl. 7.8.1961 CH-prior. 16.8.1960 2.12.1960 . US 3 539 573 Wander 10.11.1970 CH-prior. 16.8.1960 2.12.1960 20.7.1961 25.5.1962 5.12.1962 15.2.1963 22.3.1967 11.7.1967 3.11.1967 . Hunziker F. et al. Helv. Chim. Acta HCACAV 50 1588 1967 . Formulation s chewing tabl. 250 mg sol. 5 susp. 250 mg 5 ml 720 mg tabl. 125 mg 250 mg as pamoate Trade Name s D Helmex Pfizer F Combantrin Pfizer Helmintox Innotech I International J GB Combantrin Pfizer wfm Combantrin Pfizer Combantrin Pfizer 1752 p Pyrazinamide USA Antiminth Pfizer wfm Antiminth Roerig wfm Combantrin Pfizer wfm Pyrazinamide ATC J04AK01 Use tuberculostatic antibacterial RN 98-96-4 MF C5H5N3O MW 123.12 EINECS 202-717-6 LD50 1680 mg kg M i.p. 2793 mg kg M s.c. CN pyrazinecarboxamide CHO 1 4- Ti f ĩ i KMnO4 N COOH A .N COOH CHO MI N COOH Ơ 2 glyoxal o-phenylene- quinoxaline .