Đang chuẩn bị liên kết để tải về tài liệu:
Pharmaceutical Substances Syntheses, Patents, Applications - Part 185

Pharmaceutical Substances Syntheses, Patents, Applications - Part 185. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers. | Rosoxacin R 1841 Reference s a Cantello B.C.C. et al. J. Med. Chem. JMCMAR 37 3977-3985 1994 . Cantello B.C.C. et al. Bioorg. Med. Chem. Lett. BMCLE8 4 1 29. 1994 . EP 306 228 Beecham appl. 26.8.1988 GB-prior. 4.9.1987 . b Cantello B.C.C. et al. J. Chem. Soc. Perkin Trans. 1 JCPRB4 1994 3319. Heath C.M. et al. J. Chem. Technol. Biotechnol. JCTBED 68 3 324-330 1997 . WO 9 310 254 SmithKline Beecham appl. 19.11.1992 GB-prior. 19.11.1991 . c WO 9 923 095 SmithKline Beecham appl. 27.10.1998 GB-prior. 4.11.1997 . d WO 9 837 073 SmithKline Beecham appl. 13.2.1998 GB-prior. 18.2.1997 . maleate salt and other derivatives WO9405 659 SmithKline Beecham appl. 1.9.1993 GB-prior. 5.9.1992 . treatment of diabetes with insulin and rosiglitazone WO 9 837 073 SmithKline Beecham appl. 15.6.1998 GB-prior. 18.6.1997 . Formulation s tabl. 2 mg 4 mg 8 mg Trade Name s USA Avandia SmithKline Beecham 1999 Rosoxacin Acrosoxacin ATC J01MB01 Use antibiotic RN 40034-42-2 MF C17H14N2O3 MW 294.31 EINECS 254-758-4 CN 1 -ethyl-1 4-dihydro-4-oxo-7- 4-pyridinyl -3-quinolinecarboxylic acid sodium salt RN 40035-08-3 MF C17H13N2NaO3 MW 316.29 CH3COONH4 CHjCOOH ammonium acetate dimethyl 1 4-dihydro-4- 3-nitrophenyl -3 5-pyridinedicarboxylate I 0 A CH C O 3 HC 3-nitro- methyl benzoldehyde ocetylene- carboxylate 2. KOH 3. Cu2O HCI 3. copper I oxide Fe CHjCOOH 4- 3-nitraphenyl - pyridine 4- 3-ominophenyl -pyridine II diethyl ethoxymethylene-malonate l3 CH3 O diethyl 3- 4-pyridyl -anilinomethylene molonate 1842 R Roxatidine acetate ethyl 4-oxo-7- 4-pyridyl - 1 4-dihydroquinotine-3-curboxylate III ch3 O O 3 O O ethyl 1 -ethyl-4-oxo-7 4 pyridyl -1 4-díhydroquinoline-3-carboxylate IV KOH H2O IV -------------- Reference s US 3 753 993 Sterling Drug 21.8.1973 prior. 17.5.1971 . US 3 907 808 Sterling Drug 23.9.1975 prior. 17.5.1971 3.5.1973 . US 3 922 278 Sterling Drug 25.11.1975 prior. 12.6.1972 . alternative synthesis US 4 107 167 Sterling Drug 15.8.1978 prior. 17.6.1974 . Formulation s cps. 150 mg Trade Name s