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Pharmaceutical Substances Syntheses, Patents, Applications - Part 195

Pharmaceutical Substances Syntheses, Patents, Applications - Part 195. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers. | Sulfoxone sodium S 1941 Trade Name s D Inofal Sandoz wfm Sulfoxone sodium Aldesulfon Natrium ATC D08 Use chemotherapeutic leprosy RN 144-75-2 MF C14H14N2Na2O6S3 MW 448.45 LD50 10 g kg M p.o. CN sulfonylbis 4 l-phenyleneimino bis methanesulfinic acidj disodium salt free acid RN 144-76-3 MF C14HlfiN2O6S3 MW 404.49 dapsone sodium form- q. v. oldehydesulfoxylote Reference s US 2 234 981 US-Secretary of the Treasury 1941 appl. 1938 . Formulation s tabl. 330 mg Trade Name s J Diazon Joshitomi USA Diasone Sodium Abbott wfm Sulindac ATC M01AB02 Use anti-inflammatory analgesic antipyretic RN 38194-50-2 MF C20HI7FO3S MW 356.42 EINECS 253-819-2 LD50 507 mg kg M p.o. 264 mg kg R p.o. CN Z -5-fluoro-2-methyl-l- 4- methylsulfinyl phenyl methylene -l -indene-3-acetic acid 4-fluorobenz- Idehyde H-.C CH9 COONa ------il T T COOH H Pd-C ------- I propionic anhydride 4-fluoro-a-methyl -cinnomic acid 1942 S Sulmetozin rCH3 COOH polyphosphorrc ocid 95 C ------------------- 5-fluoro-2-methyl-3-indanone 1 NC -COOH CHJC00H CHjCOONH J 2. KOH J 3. HCl __ ị ------------------------------------ II 1. cyanoacetic ocid I 4-fluoro-a-methyl-dihydrocinnomic acid I 5 fluoro-2-methyl-rndene-3-acetíc acid II 4-methylthio-benzaldehyde 5-fluoro 2-methyl -1 - 4-methylthiobenzylidene -indene-3-ocetic acid III NaiO4 sodium periodate Reference s DE 2 039 426 Merck Co. appl. 7.8.1970 USA-prior. 8.8.1969 1.5.1970 . US 3 654 349 Merck Co. 4.4.1972 prior. 8.8.1969 1.5.1970 . US 3 647 858 Merck Co. 7.3.1972 prior. 19.11.1969 1.5.1970 . US 3 725 548 Merck Co. 3.4.1973 prior. 6.10.1971 . US 3 882 239 Merck Co. 6.5.1975 prior. 21.1.1971 6.9.1972 13.6.1974 . Formidatkm s tabl. 150 mg 200 mg Trade Name s Citereuma CT Clinoril Neopharmed Lyndac Eurofarmaco Sulartrene NGSN Sulen Farmacológico Milanese Sulic Crosara J USA Sulinol ICT Chinoril Merck-Banyu Clinoril Merck Sharp Dohme 1978 D Imbaral Merck Sharp Dohme 1977 wfm F Arthrocine Merck Sharp Dohme-Chibret 1977 GB Clinoril Merck Sharp Dohme 1977 I Algocetil Francia