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Pharmaceutical Substances Syntheses, Patents, Applications - Part 198

Pharmaceutical Substances Syntheses, Patents, Applications - Part 198. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers. | Tandospirone T 1971 I Omnic Yamanouchi USA Flomax Boehringer J Harnal Yamanouchi Ingelheim 1997 Tandospirone ATC N05BX SM-3997 as citrate Use anx olytic antidepressant RN 87760-53-0 MF C21H2S N5O2 MW 383.50 CN 3aa 4ß 7ß 7aa -hexahydro-2- 4- 4- 2-pyrimidinyl -l-piperazinyl butyl -4 7-methano lH-isoindole- 1 3 2Z7 -dione citrate RN 112457-95-1 MF C2IH29N5O2 . C6H8O7 MW 575.62 1- pyrimidin-2-yl -piperazine 1. NaOH H2O hAu 2. LiAIH4 -------2-------------------Ï 4- 4- pyrímidỉn-2-yl -piperazin-1 -yljbutylamine I 1.190 C 2. Hj cat. ---L----- nortorn-5-ene- 2exo.3exo-dicarboxylic ocid anhydride norbarnane-2exo 3exo-dicarboxylic acid anhydride n pyridine A II -------------- I Reference s EP 82 402 Sumitomo Chem. appl. 29.6.1983 J-prior. 22.12.1981 3.6.1982 . IP60 087 262 Sumitomo Chem. appl. 16.5.1985 USA-prior. 19.1.1983 . JP 63 010 760 Sumitomo Chem. appl. 18.1.1988 J-prior. 1.7.1986 . use ớ tandospirone a treating depression US 5 011 841 Pfizer appl. 30.4.1991 USA-prior. 14.11.1989 . b as psychotropic agents US 5 521 313 Bristol-Myers Squibb appl. 28.5.1996 USA-prior. 5.5.1994 . c as 5-HTịA-receptor agonist WO 9 605 817 Medinova SF appl. 29.2.1996 GB-prior. 23.8.1994 . 1972 T Tazanolast dosage forms US 5 330 762 Alza Corp. appl. 19.7.1994 USA-prior. 27.1.1993 . US 5 246 711 Alza Corp. appl. 21.9.1993 USA-prior. 27.2.1992 10.9.1992 . US 5 246 710 Alza Corp. appl. 22.9.1993 USA-prior. 27.2.1992 10.9.1992 . US 5 185 158 Alza Corp. appl. 9.2.1993 USA-prior. 27.2.1992 . synergistic compositions with 8-hydroxy-2- dipropylamino tetraline and idazoxan US 5 124 346 Pfizer appl. 23.6.1992 USA-prior. 23.4.1991 . synthesis ofl Kikuo I. et al. Chem. Pharm. Bull. CPBTAL 39 2288 1991 . Wu et al. J. Med. Chem. JMCMAR 15 477 1972 . Formulation s tabl. 5 mg 10 mg Trade Name s J Sediel Sumitomo Tazanolast ATC R03DX Use antiallergic antiasthmatic RN 82989-25-1 MF C13H15N5O3 MW 289.30 LD50 1121 mg kg M i.v. 4 g kg M p.o. 1119 mg kg R i.v. 4 g kg R p.o. 4 g kg dog p.o. CN oxo 3- .