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Simulation of Biological Processes phần 9

Y học hiện đại đang Bene ¢ ting từ sự phát triển của bộ gen mới và kỹ thuật proteomic, và cũng từ sự phát triển của các thiết bị hình ảnh lâm sàng phức tạp hơn bao giờ hết. Điều này sẽ có nghĩa là lâm sàng | 206 GENERAL DISCUSSION IV resolve the issue then you have people queuing up to get further understanding. This comes back to the point I emphasized earlier on. The hands on is necessary. References Jacob F Monod J 1961 Genetic regulatory mechanisms in the synthesis of proteins. J Mol Biol 3 318-356 Noble D 2002 Simulation of Na-Ca exchange activity during ischaemia. Ann NY Acad Sci in press In Silico Simulation of Biological Processes Novartis Foundation Symposium Volume 247 Edited by Gregory Bock and Jamie A. Goode Copyright Novartis Foundation 2002. ISBN 0-470-84480-9 The IUPS Physiome Project P.J. Hunter P.M.F. Nielsen and D. Bullivant Bioengineeringinstitute University of Auckland Private Bag92019 Auckland New Zealand A bstract. Modern medicine is currently benefiting from the development of new genomic and proteomic techniques and also from the development of ever more sophisticated clinical imaging devices. This will mean that the clinical assessment of a patient s medical condition could in the near future include information from both diagnostic imaging and DNA profile or protein expression data. The Physiome Project of the International Union of Physiological Sciences IUPS is attempting to provide a comprehensive framework for modelling the human body using computational methods which can incorporate the biochemistry biophysics and anatomy of cells tissues and organs. A major goal of the project is to use computational modelling to analyse integrative biological function in terms of underlying structure and molecular mechanisms. To support that goal the project is establishing web-accessible physiological databases dealing with model-related data including bibliographic information at the cell tissue organ and organ system levels. This paper discusses the development of comprehensive integrative mathematical models of human physiology based on patient-specific quantitative descriptions of anatomical structures and models of biophysical processes which .