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Báo cáo sinh học: "Untangling the web of functional and physical interactions in yeast"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Untangling the web of functional and physical interactions in yeast. | J. Biol. Journal of Biology BioMed Central Minireview Untangling the web of functional and physical interactions in yeast Markus J Herrgârd and Bernhard 0 Palsson Address Department of Bioengineering University of California San Diego 9500 Gilman Drive La Jolla CA 92093-0412 USA. Correspondence Bernhard 0 Palsson. E-mail palsson@ucsd.edu Published 8 June 2005 Journal of Biology 2005 4 5 The electronic version of this article is the complete one and can be found online at http jbiol.com content 4 2 5 2005 BioMed Central Ltd Abstract An analysis of an integrated network of over 150 000 functional and physical interactions in yeast suggests that the network can be hierarchically decomposed into themes and thematic maps. This decomposition can be used to explore the organizational principles of integrated biological networks within cells. Reconstructing the structures of the regulatory and signaling networks operating within and between cells is a key component of the systems biology approach to understanding biological processes 1 . The multitude of high-throughput datasets now available for an increasing number of model organisms has enabled the development of systematic approaches for this reconstruction task for specific types of networks. A number of approaches have been developed for identifying co-regulated gene modules from gene expression and protein-DNA binding data 2 . Similarly protein-protein interaction data have been used to reconstruct signaling networks and protein complexes 3 . These reconstructions form a blueprint of the networks operating within the cell and can be used as a starting point for further studies on network function. One of the key uses of network reconstructions is deciphering the general organizational principles of biological networks these principles that are commonly studied include topological and functional modularity 4 5 network redundancy and robustness 6 7 and pathway cross-talk 8 9 . For certain types of network including .