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Báo cáo sinh học: "RNA interference in nematodes and the chance that favored Sydney Brenner"

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Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: RNA interference in nematodes and the chance that favored Sydney Brenner. | Journal of Biology BioMed Central Minireview RNA interference in nematodes and the chance that favored Sydney Brenner Marie-Anne Felix Address Institut Jacques Monod CNRS - Universities of Paris 7 and 6 Tour 43 2 place Jussieu 75251 Paris cedex 05 France. Email felix@ijm.jussieu.fr Published 13 November 2008 Journal of Biology 2008 7 34 doi 10.1186 jbiol97 The electronic version of this article is the complete one and can be found online at http jbiol.com content 7 9 34 2008 BioMed Central Ltd Abstract The efficiency of RNA interference varies between different organisms even among nematodes. A recent report of successful RNA interference in the nematode Panagrolaimus superbus in BMC Molecular Biology has implications for the comparative study of the functional genomics of nematode species and prompts reflections on the choice of Caenorhabditis elegans as a model organism. RNA interference RNAi the inactivation of gene expression by double-stranded ds RNA has become a major method of gene inactivation in the past ten years. The fact that the trigger for RNAi is composed of dsRNA was discovered in the nematode worm Caenorhabditis elegans 1 . This gene-inactivation method is far from being applicable to all nematodes however especially in the external application mode used in C. elegans. A recent paper by Shannon et al. in BMC Molecular Biology 2 describes its successful use in two Panagrolaimus species that belong to a different nematode suborder from C. elegans. This increases the range of nematode species over which comparative functional genomics is in principle possible and reinforces the accumulating evidence that susceptibility to RNAi is widely distributed over nematode species. Is RNA interference a universal phenomenon in eukaryotes RNAi was first described in plants and has now been found in a variety of unicellular and multicellular eukaryotes. The mechanism of inhibition entails the cleavage of the dsRNA trigger into smaller dsRNAs of 21-23 base pairs .

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