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Báo cáo sinh học: "The transcriptome of human monocyte subsets begins to emerge"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: The transcriptome of human monocyte subsets begins to emerge. | Journal of Biology Minireview The transcriptome of human monocyte subsets begins to emerge Fernando O Martinez Address Sir William Dunn School of Pathology University of Oxford Oxford OX1 3RE UK. Email fernando.martinezestrada@path.ox.ac.uk Abstract Human monocytes can be divided into subsets according to their expression or lack of the cell-surface antigen CD16. In papers published recently in the Journal of Proteome Research and in BMC Genomics two groups publish independent transcriptome analyses of CD16 and CD16- monocytes with revealing results. See research article http www.biomedcentral.com 1471-2164 10 403 Monocytes are a heterogeneous group of cells constituting 5-10 of the total white blood cells in humans. They originate in the bone marrow circulate in the bloodstream and enter tissues where they differentiate into macrophages either to replenish the stock of tissue macrophages or to contribute to an inflammatory response to infection. Monocytes can remain in the circulation for up to 72 hours after which if they have not been activated they die and are removed. The heterogeneity of monocytes was noticed soon after their definition and it includes differences in density production of reactive oxygen species antigen-presenting capacity maturation status and phagocytic and adhesive properties. In 1989 Ziegler-Heitbrock and colleagues 1 noticed that human monocytes can be divided into three main populations according to their expression of the cellsurface antigens CD16 Fcy receptor III and CD14 a receptor for bacterial lipopolysaccharide LPS . The CD16 Fcy receptor is a relatively low-affinity receptor for the Fc portion of IgG antibodies in complex with their antigens and stimulates the monocyte to take up antibody-antigen complexes by phagocytosis and thus remove them from the circulation. CD14 is essential for the recognition of bacterial LPS present in Gram-negative bacteria which include many common pathogens. CD14 acts as pattern recognition protein .