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Báo cáo khoa học: "General pharmacological profiles of bee venom and its water soluble fractions in rodent models"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: General pharmacological profiles of bee venom and its water soluble fractions in rodent models | J. Vet. Sci. 2004 5 4 309-318 JOURNAL OF Veterinary Science General pharmacological profiles of bee venom and its water soluble fractions in rodent models Hyun-Woo Kim1 Young-Bae Kwon2 Tae-Won Ham1 Dae-Hyun Roh1 Seo-Yeon Yoon1 Seuk-Yun Kang1 Il-Suk Yang1 Ho-Jae Han3 Hye-Jung Lee4 Alvin J. Beitz5 Jang-Hern Lee1 1 Department of Veterinary Physiology College of Veterinary Medicine and School of Agricultural Biotechnology Seoul National University Seoul 151-742 Korea Department of Pharmacology College of Medicine ChonbukNational University Jeonju 561-756 Korea Hormone Research Center College of Veterinary Medicine Chonnam National University Gwangju 500-757 Korea Department of Acupuncture Moxibustion College of Oriental Medicine Kyung Hee University Seoul 130-701 Korea Department of Veterinary and Biomedical Sciences College of Veterinary Medicine University of Minnesota St Paul MN 55108 USA Recently the antinociceptive and anti-inflammatory efficacy of bee venom BV Apis mellifera has been confirmed in rodent models of inflammation and arthritis. Interestingly the antinociceptive and anti-inflammatory effect of whole BV can be reproduced by two water-soluble fractions of BV 20 kDa BvAF1 and 10 kDa BVAF3 . Based on these scientific findings BV and its effective water-soluble fractions have been proposed as potential anti-inflammatory and antinociceptive pharmaceuticals. While BV s anti-inflammatory and antinociceptive properties have been well documented there have been no careful studies of potential side effects of BV and its fractions when administered in the therapeutic range BV 5 gg kg BVAF1 0.2 gg kg BVAF3 3 gg kg subcutaneous or intradermal . Such information is critical for future clinical use of BV in humans. Because of this paucity of information the present study was designed to determine the general pharmacological physiological effects of BV and its fractions administration on the rodent central nervous cardiovascular respiratory and gastrointestinal .