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Báo cáo khoa học: " Subcutaneous pharmacokinetics and dosage regimen of cefotaxime in buffalo calves (Bubalus bubalis)"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Subcutaneous pharmacokinetics and dosage regimen of cefotaxime in buffalo calves (Bubalus bubalis) | J. Vet. Sci. 2006 7 2 119-122 JOURNAL OF Veterinary Science Subcutaneous pharmacokinetics and dosage regimen of cefotaxime in buffalo calves Bub al US bubalis Suresh Kumar Sharma1 Anil Kumar Srivastava2 Department of Pharmacology and Toxicology College of Veterinary Science Punjab Agricultural University Ludhiana-141 004 India 2Faculty of Veterinary Science and Animal Husbandly Sher-e-Kashmir University of Agriculture Science and Technology SKUAST R.S.Pura-181102 India The pharmacokinetics and dosage regimen of cefotaxime following its single subcutaneous administration 10 mg kg were investigated in buffalo calves. Plasma and urine samples were collected over 10 and 24 h post administration respectively. Cefotaxime in plasma and urine was estimated by microbiological assay technique using E. coll as test organism. The pharmacokinetic profiles fitted one-compartment open model. The peak plasma levels of cefotaxime were 6.48 0.52 pg ml at 30 min and the drug was detected upto 10 h. The absorption half-life and elimination halflife were 0.173 0.033 h and 1.77 0.02 h respectively. The apparent volume of distribution and total body clearance were 1.17 0.101 kg and 0.45 0.03 1 kg h respectively. The urinary excretion of cefotaxime in 24 h was 5.36 1.19 percent of total administrated dose. A satisfactory subcutaneous dosage regimen for cefotaxime in buffalo calves would be 13 mg kg repeated at 12 h intervals. Key words buffalo calf cefotaxime dosage regimen pharmacokinetics Introduction Cefotaxime was the first of the thứd generation cephalosporins to be released in the market. It is broad spectrum antibiotic and highly resistant to the action of P-lactamase enzyme. Against gram negative micro organisms it exhibits greater in vitro activity than any of the previous cephalosporins 14 Pharmacokinetic studies of antimicrobial agents which provide a basis for the determination of theft satisfactory dosage regimen are relevant when they are undertaken in the species in which .