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Báo cáo y học: "Natural History and Clinical Consequences of Hepatitis B Virus Infection"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Natural History and Clinical Consequences of Hepatitis B Virus Infection. | Int. J. Med. Sci. 2005 2 1 36 Review Received 2004.10.01 Accepted 2005.01.02 Published 2005.01.05 Abstract Key words Author biography Corresponding address International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2005 2 1 36-40 2005 Ivyspring International Publisher. All rights reserved Natural History and Clinical Consequences of Hepatitis B Virus Infection Calvin Q. Pan1 and Jin X. Zhang2 1 Division of Gastroenterology and Hepatology Elmhurst Hospital Center of Mount Sinai Services Mount Sinai School of MediCine New York USA 2 Division of Gastroenterology Mount Sinai Hospital Mount Sinai School of Medicine New York USA Despite the existence of Hepatitis B vaccination hepatitis B virus HBV infection is still prevalent worldwide and accounts for significant morbidity and mortality. It is encouraging that majority of patients do recover from the acute infection however those that progress to chronic disease state is at great risk of developing complications such as hepatocellular carcinoma cirrhosis and liver failure. Hepatitis B virus infection can be influenced by many factors such as host immune status age at infection and level of viral replication. The discovery about the existence of various genotypes and its association with different geographic distribution as well as the knowledge regarding mutant species has aid us in better understanding the nature of HBV infection and in delivering better care for patients. It is especially important to recognize those individuals with HBeAg-negative chronic HBV as they have a poorer prognosis compare with their counterparts HBeAg-positive. Tremendous progress has been made over the years in understanding the behavior and clinical course of the disease however the natural history of HBV is complex and we still have much to explore and learn. Hepatitis B natural history cirrhosis hepatocellular carcinoma Calvin Q. Pan MD is a Faculty of Gastroenterology and Hepatology Fellowship Program at Mount Sinai .