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Báo cáo y học: " Carotid Intima-media thickness in childhood and adolescent obesity relations to abdominal obesity, high triglyceride level and insulin resistance"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Carotid Intima-media thickness in childhood and adolescent obesity relations to abdominal obesity, high triglyceride level and insulin resistance. | Int. J. Med. Sci. 2010 7 278 International Journal of Medical Sciences 2010 7 5 278-283 Ivyspring International Publisher. All rights reserved Research Paper Carotid Intima-media thickness in childhood and adolescent obesity relations to abdominal obesity high triglyceride level and insulin resistance Jie Fang Jian Ping Zhang Cai Xia Luo Xiao Mei Yu Lan Qiu Lv Department of Endocrinology Ningbo Women and Children s Hospital Ningbo 315000 China H Corresponding author Jie Fang Department of Endocrinology Ningbo Women and Children s Hospital Ningbo 315000 China. Tel 86-13957882013 E-mail fangjie121108@yahoo.com.cn Received 2010.04.13 Accepted 2010.08.08 Published 2010.08.18 Abstract Aim To investigate risk factors which impact on common carotid artery intima media thickness IMT . Methods A total of 86 obese children and adolescents and 22 healthy children and adolescents with normal weight were enrolled. Moreover 23 of 86 obese children and adolescents were diagnosed with metabolic syndrome MetS . The clinical biochemical data and the IMT of the common carotid artery were measured in all subjects. Results Obese and obese with MetS subjects demonstrated a significantly p 0.01 thicker intima media 0.69mm 0.66mm as compared to the control group 0.38mm but there was no significant difference of IMT between obese and MetS group. IMT was correlated to body weight body mass index waist circumference waist to hip ratio systolic blood pressure diastolic blood pressure fasting insulin homoeostasis model assessment-insulin resistance triglyceride high-density lipoprotein- cholesterol low-density lipoprotein-cholesterol alanine aminotransferase aspartate aminotransferase and fatty liver. Waist circumference waist to hip ratio triglyceride and homoeostasis model assessment-insulin resistance were independent determinants of mean IMT level. Conclusion Obesity especially abdominal obesity high TG and insulin resistance may be the main risk predictors of increased IMT. Key words .