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Báo cáo sinh học: "Evaluating antibiotics for use in medicine using a poloxamer biofilm model"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Clinical Microbiology đề tài: Evaluating antibiotics for use in medicine using a poloxamer biofilm model. | Annals of Clinical Microbiology and Antimicrobials BioMed Central Open Access Evaluating antibiotics for use in medicine using a poloxamer biofilm model Abi L Clutterbuck1 3 Christine A Cochrane2 3 Jayne Dolman3 and Steven L Percival 3 Address University of Wales Institute of Rural Studies Aberystwyth Ceredigion Wales SY23 3AL UK 2University of Liverpool Department of Veterinary Clinical Science Division of Equine Studies Leahurst Neston South Wirral CH64 7TE UK and 3ConvaTec Wound Therapeutics GDC First Avenue Deeside Industrial Park Deeside CH5 2NU UK Email Abi L Clutterbuck - abiclutterbuck@gmail.com Christine A Cochrane - C.A.Cochrane@liverpool.ac.uk Jayne Dolman - Jayne.dolman@bms.com Steven L Percival - steven.percival@bms.com Corresponding author Published 15 February 2007 Received 13 December 2006 Annals of Clinical Microbiology and Antimicrobials 2007 6 2 doi l0.ll86 l 476-0711-6-2 Accepted I5 February 2007 This article is available from http www.ann-clinmicrob.cOm content 6 1 2 2007 Clutterbuck et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Wound infections due to biofilms are a constant problem because of their recalcitrant nature towards antibiotics. Appropriate antibiotic selection for the treatment of these biofilm infections is important. The traditional in vitro disc diffusion method for antibiotic selection uses bacterial cultures grown on agar plates. However the form of bacterial growth on agar is not representative of how bacteria grow in wounds and other tissue sites as here bacteria grow naturally in a biofilm. The aim of this research was to test a more appropriate method for testing .