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Báo cáo y học: "Brain choline concentrations may not be altered in euthymic bipolar disorder patients chronically treated with either lithium or sodium valproate"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Brain choline concentrations may not be altered in euthymic bipolar disorder patients chronically treated with either lithium or sodium valproate. | Annals of General Hospital Psychiatry Primary research BioMed Central Open Access Brain choline concentrations may not be altered in euthymic bipolar disorder patients chronically treated with either lithium or sodium valproate Ren H Wu1 Tina O Donnell2 Michele Ulrich2 Sheila J Asghar2 Christopher C Hanstock1 and Peter H Silverstone 2 Address Department of Biomedical Engineering University of Alberta Edmonton Alberta Canada and 2Department of Psychiatry University of Alberta Edmonton Alberta Canada Email Ren H Wu - wurh20000@sina.com Tina O Donnell - tina@gpu.srv.ualberta.ca Michele Ulrich - mulrich@ualberta.ca Sheila J Asghar - sheila_canada@yahoo.com Christopher C Hanstock - chris.hanstock@ualberta.ca Peter H Silverstone - peter.silverstone@ualberta.ca Corresponding author Published 30 July 2004 Received 30 September 2003 Annals of General Hospital Psychiatry 2004 3 13 doi 10.1186 1475-2832-3-13 Accepted 30 July 2004 This article is available from http www.general-hospital-psychiatry.eom content 3 1 13 2004 Wu et al licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background It has been suggested that lithium increases choline concentrations although previous human studies examining this possibility using 1H magnetic resonance spectroscopy 1H MRS have had mixed results some found increases while most found no differences. Methods The present study utilized 1H MRS in a 3 T scanner to examine the effects of both lithium and sodium valproate upon choline concentrations in treated euthymic bipolar patients utilizing two different methodologies. In the first part of the study healthy controls n 18 were compared with euthymic Bipolar Disorder patients Type I and Type II who were taking either lithium n 14 or sodium .