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Báo cáo y học: "Annual Scientific Meeting, Winnipeg, September 22-25, 2005"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Annual Scientific Meeting, Winnipeg, September 22-25, 2005. | Eck et al. Allergy Asthma Clinical Immunology 2005 1 101 http www.aacijournal.eom content 1 3 101 ALLERGY ASTHMA CLINICAL IMMUNOLOGY MEETING ABSTRACTS Open Access Annual Scientific Meeting Winnipeg September 22-25 2005 Natural History of Peanut Allergy R. Borici-Mazi J.A. Mazza D.W. Moote K. Payton Division of Allergy and Clinical Immunology University of Western Ontario London ON Background Peanut allergy affects 0.5 to 1 of the general population. Despite enormous efforts to educate peanut allergic patients and their families and increasing public awareness of hidden sources of peanuts accidental exposures to peanuts still happen. The aim of this study was to calculate the cumulative risk of accidental exposures to peanut among peanut allergic patients and to study their effect on peanut-specific IgE levels PN-IgE . Methods This was a retrospective chart review of peanut allergic patients followed up at LHSC from 1997 to 2004. Peanut allergic patients who were less than 15 years old at the time of first reaction to peanut and had serial measurements of PN-IgE were included in the study. Diagnosis of peanut allergy was based on significant history of acute reaction and positive SPT PN-IgE to peanut. Statistical Analysis Cumulative risk of accidental exposures and time to significant change of PN-IgE were calculated using Kaplan-Meiers survival curves. Comparisons were made using the log-rank statistics. Results Medical charts from 118 peanut allergic patients were reviewed median age at first reaction was 1.5 years old baseline PN-IgE value was 18.75 kUA L . Ninety-four patients decreased their PN-IgE levels whereas 24 experienced elevation of PN-IgE. There were 88 reported accidental exposures in 64 patients and 17 patients experienced more than one accidental exposure. Calculated cumulative risk of reported accidental exposures at 1 5 and 10 years post initial reaction was 24.8 34 and 65.1 respectively. Conclusion The predicting factors that determine resolution