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Báo cáo y học: "Intramuscular Olanzapine – a UK case series of early cases"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Intramuscular Olanzapine – a UK case series of early cases. | Annals of General Psychiatry BioMed Central Open Access Intramuscular Olanzapine - a UK case series of early cases Chris J Bushe 1 Mark Taylor2 and Mathew Mathew3 Address 1Eli Lilly and Company Ltd Basingstoke UK 2Springpark Centre Glasgow G22 5EU UK and 3Stonehouse Hospital Dartford DA2 6AU UK Email Chris J Bushe - bushe_chris@lilly.com Mark Taylor - Mark.Taylor@glacomen.scot.nhs.uk Mathew Mathew - mathew@vmmathew.fsnet.co.uk Corresponding author Published I April 2007 Received 1 November 2006 Annals of General Psychiatry 2007 6 11 doi 10.1186 1744-859X-6-1 1 Accepted 1 April 2007 This article is available from http www.annals-general-psychiatry.cOm content 6 1 11 2007 Bushe et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Clinical trials assessing efficacy and safety of Intramuscular IM Olanzapine in acute schizophrenia and acute mania have previously been undertaken in studies required for drug registration in patients who were required to give informed consent. These patients may have less severe forms of psychosis than patients treated in routine practice. Data derived from naturalistic practice following the launch of IM olanzapine may be helpful for clinicians in assessing efficacy and safety of IM olanzapine. The PANSS-EC scale used in the clinical studies may represent a tool that could be used in routine clinical practice. Case presentation We report on an early unselected case series of 7 patients who received IM olanzapine in routine clinical practice settings in the UK. In this case series olanzapine IM was generally effective and no adverse events were reported. Adjunctive benzodiazepines were given concomitantly in 1 of the 7 subjects. This is relevant as concomitant benzodiazepines .