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Báo cáo y học: "Antibodies to mutated citrullinated vimentin for diagnosing rheumatoid arthritis in anti-CCP-negative patients and for monitoring infliximab therapy"

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Antibodies to mutated citrullinated vimentin for diagnosing rheumatoid arthritis in anti-CCP-negative patients and for monitoring infliximab therapy. | Available online http arthritis-research.eom content 10 6 R142 Research article Antibodies to mutated citrullinated vimentin for diagnosing rheumatoid arthritis in anti-CCP-negative patients and for monitoring infliximab therapy Pascale Nicaise Roland1 Sabine Grootenboer Mignot1 Alessandra Bruns2 Margarita Hurtado1 3 Elisabeth Palazzo2 Gilles Hayem2 Philippe Dieudé2 Olivier Meyer2 and Sylvie Chollet Martin1 3 Immunology and Haematology Department Bichat-Claude Bernard Teaching Hospital AP-HP 46 rue H Huchard 75877 Paris Cedex 18 France 2Rheumatology Department Bichat-Claude Bernard Teaching Hospital AP-HP 46 rue H Huchard 75877 Paris Cedex 18 France 3Inserm IFR 141 UMR756 Paris-South 11 University 5 rue JB Clement 92296 Chatenay-Malabry Cedex France Corresponding author Pascale Nicaise Roland pascale.nicaise@bch.aphp.fr Received 15 Jul 2008 Revisions requested 12 Aug 2008 Revisions received 26 Nov 2008 Accepted 10 Dec 2008 Published 1 0 Dec 2008 Arthritis Research Therapy 2008 10 R142 doi 10.1186 ar2570 This article is online at http arthritis-research.com content 10 6 R142 2008 Nicaise Roland et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Antibodies against eyelie citrullinated peptides CCPs are useful for diagnosing rheumatoid arthritis RA . Antibodies to mutated citrullinated vimentin MCV were described recently in RA. The aims of this study were to evaluate the usefulness of anti-MCV for diagnosing RA in anti-CCP-negative patients and to monitor anti-MCV titres during infliximab therapy for RA. Methods We studied two groups of RA patients one with n 80 and one without n 76 anti-CCP antibodies. The specificity of anti-MCV was evaluated by investigating 50 healthy controls and 158

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