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Báo cáo y học: "Diagnostic value of anti-topoisomerase I antibodies in a large monocentric cohort"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Diagnostic value of anti-topoisomerase I antibodies in a large monocentric cohort. | Available online http arthritis-research.eom content 11 1 R28 Research article Diagnostic value of anti-topoisomerase I antibodies in a large monocentric cohort Katharina Hanke1 Cornelia Dahnrich2 Claudia S Bruckner1 Dorte Huscher3 Mike Becker1 Anthonina Jansen2 Wolfgang Meyer2 Karl Egerer1 Falk Hiepe1 Gerd R Burmester1 Wolfgang Schlumberger2 and Gabriela Riemekasten1 Open Access Department of Rheumatology and Clinical Immunology Charité Universitatsmedizin Berlin Chariteplatz 1 Berlin 10117 Germany 2EUROIMMUN Medizinische Labordiagnostika AG Seekamp 31 Lubeck 23560 Germany 3German Rheumatism Research Centre Chariteplatz 1 Berlin 10117 Germany Corresponding author Gabriela Riemekasten gabriela.riemekasten@charite.de Received 8 Sep 2008 Revisions requested 20 Oct 2008 Revisions received 21 Jan 2009 Accepted 21 Feb 2009 Published 21 Feb 2009 Arthritis Research Therapy 2009 11 R28 doi 10.1186 ar2622 This article is online at http arthritis-research.com content 11 1 R28 2009 Hanke et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction In the present study the detection of antitopoisomerase I anti-topo I autoantibodies was evaluated for diagnosis and risk assessment of systemic sclerosis SSc patients in a well characterized large monocentric cohort. Methods Sera from patients with SSc diffuse n 96 limited n 113 from patients with overlap syndromes n 51 from patients with other diseases associated with SSc n 20 as well as from disease controls n 487 were analysed for the presence of anti-topo I antibodies by line immunoblot assay and ELISA. Assessment of organ manifestations was performed as proposed by the European Scleroderma Trial and Research network. Results The applied test systems for the detection of