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Báo cáo y học: "Practical and theoretical barriers to the prevention of accelerated atherosclerosis in systemic lupus erythematosus"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Practical and theoretical barriers to the prevention of accelerated atherosclerosis in systemic lupus erythematosus. | Arthritis Research Therapy Vol 5 No 4 Costenbader and Liang Commentary SLE Practical and theoretical barriers to the prevention of accelerated atherosclerosis in systemic lupus erythematosus Karen H Costenbader1 2 3 and Matthew H Liang1 3 4 1The Robert B. Brigham Arthritis and Musculoskeletal Disease Clinical Research Center Brigham and Women s Hospital Boston Massachusetts USA 2Department of Medicine Massachusetts General Hospital Boston Massachusetts USA 3Harvard Medical School Boston Massachusetts USA 4Department of Medicine Brigham and Women s Hospital Boston Massachusetts USA Corresponding author Karen H Costenbader e-mail kcostenbader@partners.org Received 10 Mar 2003 Revisions requested 4 Apr 2003 Revisions received 24 Apr 2003 Accepted 30 Apr 2003 Published 23 May 2003 Arthritis Res Ther 2003 5 178-179 DOI 10.1186 ar773 2003 BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 Abstract Accelerated atherosclerotic vascular disease ASVD is a major cause of death in systemic lupus erythematosus SLE . Although many authorities are calling for aggressive assessment and management of cardiac risk factors in patients with SLE both theoretical and practical barriers to this approach exist. It seems that SLE and or its treatment are themselves strong risk factors for the development of ASVD and it is unclear how much this risk can be decreased by the control of traditional risk factors. Studies from several centers have shown that suboptimal risk factor management and barriers to acceptance of these measures must also be studied further. Keywords atherosclerosis cardiac risk factor coronary artery disease systemic lupus erythematosus Introduction Aggressive and accelerated atherosclerosis is a major problem in systemic lupus erythematosus SLE and is one of its major causes of death an observation first made more than 20 years ago by Urowitz 1 . Coronary artery disease develops in 6-9 of SLE patients and accounts for up to 36.4 of deaths in SLE. High rates .