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Báo cáo y học: "Serum levels of cartilage oligomeric matrix protein are elevated in rheumatoid arthritis, but not in inflammatory rheumatic diseases such as psoriatic arthritis, reactive arthritis, Raynaud’s syndrome, scleroderma, systemic lupus erythematosus, vasculitis and Sjögren’s syndrome"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Serum levels of cartilage oligomeric matrix protein are elevated in rheumatoid arthritis, but not in inflammatory rheumatic diseases such as psoriatic arthritis, reactive arthritis, Raynaud’s syndrome, scleroderma, systemic lupus erythematosus, vasculitis and Sjögren’s syndrome. | Available online http arthritis-research.eom content 6 2 73 Letter Serum levels of cartilage oligomeric matrix protein are elevated in rheumatoid arthritis but not in inflammatory rheumatic diseases such as psoriatic arthritis reactive arthritis Raynaud s syndrome scleroderma systemic lupus erythematosus vasculitis and Sjogren s syndrome Martin Skoumal1 2 Gunther Haberhauer2 3 Josef Feyertag3 Eva Maria Kittl4 Kurt Bauer4 and Attila Dunky3 1 Rheumasonderkrankenanstalt der SVA der gewerblichen Wirtschaft Baden Austria 2Institut fur Rheumatologie der Kurstadt Baden in Kooperation mit der Donauuniversitat Krems Baden Austria 3Fifth Department of Internal Medicine Rheumatology Wilhelminen-Hospital Vienna Austria 4Central Laboratory Danube Hospital Vienna Austria Corresponding author Martin Skoumal e-mail martin.skoumal@a1.net Received 20 Aug 2003 Revisions requested 7 Oct 2003 Revisions received 28 Jan 2004 Accepted 18 Feb 2004 Published 8 Mar 2004 Arthritis Res Ther 2004 6 73-74 DOI 10.1186 ar1161 2004 BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 Progressive bone and cartilage destruction in arthritic joints leads to irreversible joint destruction and subsequently to functional declines and to work disability. During recent years a lot of interest has been focused on serum biomarkers in the clinic to evaluate the ongoing disease process in the cartilage and bone. New biomarkers such as osteoprotegerin or receptor activator of NF-kB ligand have been developed to describe the local bone process in affected joints. Cartilage oligomeric matrix protein in serum sCOMP is a biomarker for the cartilage turnover 1 and is elevated in patients with rheumatoid arthritis RA in patients with osteoarthritis and in patients with articular trauma. sCOMP is a valuable parameter for the assessment of therapy response in RA 2 . Elevated serum levels of sCOMP showed a significant correlation with the progression of the Larsen score within 5 years in a patient group with .