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báo cáo khoa học: "Retroperitoneal liposarcomas: the experience of a tertiary Asian center"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Retroperitoneal liposarcomas: the experience of a tertiary Asian center | Lee et al. World Journal of Surgical Oncology 2011 9 12 http www.wjso.eom content 9 1 12 5 t WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Retroperitoneal liposarcomas the experience of a tertiary Asian center Ser Yee Lee1 2 Brian Kim Poh Goh1 Melissa Ching Ching Teo1 2 Min Hoe Chew1 Pierce Kah Hoe Chow1 2 3 Wai Keong Wong1 2 3 London LPJ Ooi1 2 3 Khee Chee Soo1 2 3 Abstract Background Liposarcoma is the single most common soft tissue sarcoma in the retroperitoneum. Materials and methods A retrospective review of patients with primary retroperitoneal liposarcoma treated between June 1990 and June 2005 were conducted to evaluate the clinical results of resection for retroperitoneal liposarcomas RPLS and the prognostic factors for disease recurrence and patient survival in an Asian population. Results Twenty-one patients operated on for curative intent 12 Males 9 Females mean age 52.4 years were evaluated. Of these 13 presented with tumors that were well differentiated 61.9 4 19.0 with myxoid round cell 3 14.3 with dedifferentiated and 1 4.8 with pleomorphic morphology. The median tumor burden was 36 cm 9-83 . Median follow-up time was 62 months. There was no peri-operative mortality and morbidity occurred in 6 28.6 patients. Surgical margins were involved in 10 47.6 patients. Resection of contiguous organs was required in 15 71.4 to achieve gross surgical margins. Eleven out of the 21 52 of the patients had recurrence of the tumor. Median disease-free survival was 19 months and the overall 3- and 5-year survival rate was 87 and 49 respectively. Conclusion An aggressive surgical approach in both primary and recurrent RPLS in our institution is associated with 3- and 5-year survival rate of 87 and 49 respectively. Contiguous organ resection is often required to achieve local control. Introduction Soft tissue sarcomas are rare and account for less than 1 of all newly diagnosed malignancies. One third of malignant tumors that arise in the retroperitoneum are .