Đang chuẩn bị liên kết để tải về tài liệu:
báo cáo khoa học: "Gastrointestinal Stromal Tumours treated before and after the advent of c-kit immunostaining"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Gastrointestinal Stromal Tumours treated before and after the advent of c-kit immunostaining | Sorelli et al. World Journal of Surgical Oncology 2011 9 44 http www.wjso.eom content 9 1 44 5 t WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Gastrointestinal Stromal Tumours treated before and after the advent of c-kit immunostaining Paolo G Sorelli1 Patrizia Cohen2 Bafour Amo-Takyi2 Nikitas A Theodorou1 and Peter M Dawson1 Abstract Background Recently developed immunohistochemical markers have revolutionised the classification of gastrointestinal stromal tumours GISTs whilst tyrosine kinase inhibitors imatinib have had a significant impact on the treatment of advanced tumours. We review the clinicopathological features of previously resected mesenchymal tumours of the gastrointestinal tract in our institution to 1 reclassify the histological diagnosis of those stained prior to c-kit availability 2 perform survival analysis to identify prognostic factors and 3 to consider the implications for patients. Methods Clinicopathological records of patients with a diagnosis of mesenchymal tumours treated between May 1992 and April 2007 were reviewed. Results 82 patients were reviewed. 26 32 were reclassified as GISTs following c-kit immunostaining and a further 14 patients were treated for GIST up to April 2007 Total 40 patients 21 males and 19 females mean age 67 range 30-92 years . 36 90 underwent complete resection. 5-year survival of patients with GIST alone was 80 . Females had a better median survival M F 43 months 73 months . Conclusions The availability of c-kit staining allowed 32 of previously diagnosed mesenchymal tumours to be reclassified as GISTs. This may have implications for the follow-up of patients diagnosed prior to the availability of this method. Introduction Gastrointestinal stromal tumours GISTs are the most common form of mesenchymal connective tissue tumours of the GI tract. They are rare and represent approximately 0.3-3 of all gastrointestinal tumours 1 . In the last decade studies have discovered that nearly all GISTs are .