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Báo cáo khoa học: "Lymph node metastasis in grossly apparent clinical stage Ia epithelial ovarian cancer: Hacettepe experience and review of literature"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Lymph node metastasis in grossly apparent clinical stage Ia epithelial ovarian cancer: Hacettepe experience and review of literature | Desteli et al. World Journal of Surgical Oncology 2010 8 106 http www.wjso.eom content 8 1 106 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Lymph node metastasis in grossly apparent clinical stage la epithelial ovarian cancer Hacettepe experience and review of literature Guldeniz Aksan Desteli1 Murat Gultekin2 Alp Usubutun3 Kunter Yuce4 Ali Ayhan1 Abstract Background Lymphadenectomy is an integral part of the staging system of epithelial ovarian cancer. However the extent of lymphadenectomy in the early stages of ovarian cancer is controversial. The objective of this study was to identify the lymph node involvement in unilateral epithelial ovarian cancer apparently confined to the one ovary clinical stage Ia . Methods A prospective study of clinical stage I ovarian cancer patients is presented. Patient s characteristics and tumor histopathology were the variables evaluated. Results Thirty three ovarian cancer patients with intact ovarian capsule were evaluated. Intraoperatively neither of the patients had surface involvement adhesions ascites or palpable lymph nodes supposed to be clinical stage Ia . The mean age of the study group was 55.3 11.8. All patients were surgically staged and have undergone a systematic pelvic and paraaortic lymphadenectomy. Final surgicopathologic reports revealed capsular involvement in seven patients 21.2 contralateral ovarian involvement in two 6 and omental metastasis in one 3 patient. There were two patients 6 with lymph node involvement. One of the two lymph node metastasis was solely in paraaortic node and the other metastasis was in ipsilateral pelvic lymph node. Ovarian capsule was intact in all of the patients with lymph node involvement and the tumor was grade 3. Conclusion In clinical stage Ia ovarian cancer patients there may be a risk of paraaortic and pelvic lymph node metastasis. Further studies with larger sample size are needed for an exact conclusion. Background Epithelial ovarian carcinoma EOC is a lethal .