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Báo cáo y học: "Peripheral blood but not synovial fluid natural killer T cells are biased towards a Th1-like phenotype in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Peripheral blood but not synovial fluid natural killer T cells are biased towards a Th1-like phenotype in rheumatoid arthritis. | Available online http arthritis-research.eom content 7 3 R493 Research article Peripheral blood but not synovial fluid natural killer T cells are biased towards a Th1-like phenotype in rheumatoid arthritis Loes Linsen Marielle Thewissen Kurt Baeten Veerle Somers Piet Geusens Jef Raus and Piet Stinissen Biomedisch Onderzoeksinstituut Limburgs Universitair Centrum and School of Life Sciences Transnationale Universiteit Limburg Universitaire Campus Diepenbeek Belgium Corresponding author Piet Stinissen piet.stinissen@luc.ac.be Received 13 Oct 2004 Revisions requested 17 Nov 2004 Revisions received 1 4 Jan 2005 Accepted 19 Jan 2005 Published 18 Feb 2005 Arthritis Research Therapy 2005 7 R493-R502 DOI 10.11 86 ar1695 This article is online at http arthritis-research.com content 7 3 R493 2005 Linsen et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Natural killer T NKT cells have been implicated in the regulatory immune mechanisms that control autoimmunity. However their precise role in the pathogenesis of rheumatoid arthritis RA remains unclear. The frequency cytokine profile and heterogeneity of NKT cells were studied in peripheral blood mononuclear cells PBMCs from 23 RA patients and 22 healthy control individuals including paired PBMC-synovial fluid samples from seven and paired PBMC-synovial tissue samples from four RA patients. Flow cytometry revealed a decreased frequency of NKT cells in PBMCs from RA patients. NKT cells were present in paired synovial fluid and synovial tissue samples. Based on the reactivity of PBMC-derived NKT cells toward a-galactosylceramide RA patients could be divided into responders 53.8 and nonresponders 46.2 . However NKT cells isolated from synovial fluid from both .