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Báo cáo y học: "Knee cartilage loss in symptomatic knee osteoarthritis over 4.5 years"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Knee cartilage loss in symptomatic knee osteoarthritis over 4.5 years. | Available online http arthritis-research.eom content 8 4 R90 Research article Knee cartilage loss in symptomatic knee osteoarthritis over 4.5 years Anita E Wluka1 2 Andrew Forbes1 Yuanyuan Wang1 Fahad Hanna1 Graeme Jones3 and Flavia M Cicuttini1 1 Department of Epidemiology and Preventive Medicine Monash University - Central and Eastern Clinical School Alfred Hospital Commercial Road Melbourne VIC 3004 Australia 2Baker Heart Research Institute 75 Commercial Road Prahran VIC 3181 Australia 3Menzies Research Institute University of Tasmania Hobart 1 7 Liverpool St Hobart TAS 7000 Australia Corresponding author Flavia M Cicuttini flavia.cicuttini@med.monash.edu.au Received 5 Jan 2006 Revisions requested 27 Jan 2006 Revisions received 19 Apr 2006 Accepted 21 Apr 2006 Published 16 May 2006 Arthritis Research Therapy 2006 8 R90 doi 10.1186 ar1 962 This article is online at http arthritis-research.com content 8 4 R90 2006 Wluka et al licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract The objective of this study was to describe the rate of change in knee cartilage volume over 4.5 years in subjects with symptomatic knee osteoarthritis OA and to determine factors associated with cartilage loss. One hundred and five subjects were eligible for this longitudinal study. Subjects tibial cartilage volume was assessed by magnetic resonance imaging MRI at baseline at 2 years and at 4.5 years. Of 105 subjects 78 74 completed the study. The annual percentage losses of medial and lateral tibial cartilage over 4.5 years were 3.7 4.7 mean SD 95 confidence interval 2.7 to 4.8 and 4.4 4.7 mean SD 95 confidence interval 3.4 to 5.5 respectively. Cartilage volume in each individual seemed to track over the study period relative to .