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Báo cáo y học: "Inhibition of protein geranylgeranylation induces apoptosis in synovial fibroblasts"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Inhibition of protein geranylgeranylation induces apoptosis in synovial fibroblasts. | Available online http arthritis-research.eom content 8 4 R94 Open Access Research article Inhibition of protein geranylgeranylation induces apoptosis in synovial fibroblasts Alison M Connor1 Stuart Berger1 Aru Narendran2 and Edward C Keystone3 1The Wellesley Toronto Arthritis and Immune Disorder Research Centre 101 College St. Toronto Ontario Canada M5G 1 L7 2Southern Alberta Children s Cancer Program Alberta Children s Hospital 1820 Richmond Road SW Calgary Alberta Canada T2T 5C7 3The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease Mount Sinai Hospital 60 Murray Street Toronto Ontario Canada M5T 3L9 Corresponding author Edward C Keystone edkeystone@mtsinai.on.ca Received 23 Feb 2006 Revisions requested 21 Apr 2006 Revisions received 1 May 2006 Accepted 4 May 2006 Published 14 Jun 2006 Arthritis Research Therapy 2006 8 R94 doi 10.1186 ar1 968 This article is online at http arthritis-research.com content 8 4 R94 2006 Connor et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Statins competitive inhibitors of hydroxymethylglutaryl-CoA reductase have recently been shown to have a therapeutic effect in rheumatoid arthritis RA . In RA synovial fibroblasts in the synovial lining are believed to be particularly important in the pathogenesis of disease because they recruit leukocytes into the synovium and secrete angiogenesis-promoting molecules and proteases that degrade extracellular matrix. In this study we show a marked reduction in RA synovial fibroblast survival through the induction of apoptosis when the cells were cultured with statins. Simvastatin was more effective in RA synovial fibroblasts than atorvastatin and both statins were more potent on tumor necrosis factor-a-induced cells. In contrast