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Báo cáo y học: "Induction of tumour necrosis factor receptor-expressing macrophages by interleukin-10 and macrophage colony-stimulating factor in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Induction of tumour necrosis factor receptor-expressing macrophages by interleukin-10 and macrophage colony-stimulating factor in rheumatoid arthritis. | Available online http arthritis-research.eom content 8 4 R1 26 Research article Induction of tumour necrosis factor receptor-expressing macrophages by interleukin-10 and macrophage colony-stimulating factor in rheumatoid arthritis Koji Takasugi1 Masahiro Yamamura2 Mitsuhiro Iwahashi1 Fumio Otsuka1 Jiro Yamana1 Katsue Sunahori1 Masanori Kawashima1 Masao Yamada3 and Hirofumi Makino1 Open Access Department of Medicine and Clinical Science Graduate School of Medicine Dentistry Pharmaceutical Sciences Okayama University 2-5-1 Shikata-cho Okayama 700-8558 Japan 2Department of Rheumatology School of Medicine Aichi Medical University Nagakute-cho Aichi 480-11 95 Japan 3Department of Virology Graduate School of Medicine Dentistry Pharmaceutical Sciences 2-5-1 Shikata-cho Okayama 700-8558 Japan Corresponding author Masahiro Yamamura yamamura@aichi-med-u.ac.jp Received 30 Mar 2006 Revisions requested 11 May 2006 Revisions received 10 Jul 2006 Accepted 17 Jul 2006 Published 19 Jul 2006 Arthritis Research Therapy 2006 8 R126 doi 10.1186 ar2015 This article is online at http arthritis-research.com content 8 4 R1 26 2006 Takasugi et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Despite its potent ability to inhibit proinflammatory cytokine synthesis interleukin IL -10 has a marginal clinical effect in rheumatoid arthritis RA patients. Recent evidence suggests that IL-10 induces monocyte macrophage maturation in cooperation with macrophage-colony stimulating factor M-CSF . In the present study we found that the inducible subunit of the IL-10 receptor IL-10R type 1 IL-10R IL-10R1 was expressed at higher levels on monocytes in RA than in healthy controls in association with disease activity while their expression of both type