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Báo cáo y học: "Differential gene expression of bone anabolic factors and trabecular bone architectural changes in the proximal femoral shaft of primary hip osteoarthritis patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Differential gene expression of bone anabolic factors and trabecular bone architectural changes in the proximal femoral shaft of primary hip osteoarthritis patients. | Available online http arthritis-research.eom content 8 6 R188 Research article Differential gene expression of bone anabolic factors and trabecular bone architectural changes in the proximal femoral shaft of primary hip osteoarthritis patients Le-Hoa Truong1 2 Julia S Kuliwaba1 2 Helen Tsangari1 and Nicola L Fazzalari1 2 1 Bone and Joint Research Laboratory Division of Tissue Pathology Institute of Medical and Veterinary Science and the Hanson Institute Frome Road Adelaide 5000 Australia 2Discipline of Pathology School of Medical Sciences The University of Adelaide Frome Road Adelaide 5005 Australia Corresponding author Julia S Kuliwaba julia.kuliwaba@imvs.sa.gov.au Received 13 Oct 2006 Revisions requested 7 Nov 2006 Revisions received 4 Dec 2006 Accepted 22 Dec 2006 Published 22 Dec 2006 Arthritis Research Therapy 2006 8 R188 doi 10.1186 ar2101 This article is online at http arthritis-research.com content 8 6 R188 2006 Truong et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Previous studies have shown a generalised increase in bone mass in patients with osteoarthritis OA . Using molecular histomorphometry this study examined the in vivo expression of mRNA encoding bone anabolic factors and collagen type I genes COL1A1 COL1A2 in human OA and non-OA bone. Bone samples were obtained from the intertrochanteric IT region of the proximal femur a skeletal site distal to the active site of disease from individuals with hip OA at joint replacement surgery and from autopsy controls. Semi-quantitative reverse transcription-polymerase chain reaction analysis revealed elevated mRNA expression levels of alkaline phosphatase p 0.002 osteocalcin OCN p 0.0001 osteopontin p 0.05 COL1A1 p 0.0001 and COL1A2 p 0.002