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Báo cáo khoa học: "Age is not a limiting factor for brachytherapy for carcinoma of the node negative oral tongue in patients aged eighty or older"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Age is not a limiting factor for brachytherapy for carcinoma of the node negative oral tongue in patients aged eighty or older. | Yamazaki et al. Radiation Oncology 2010 5 116 http www.ro-journal.eom content 5 1 116 RADIATION ONCOLOGY RESEARCH Open Access Age is not a limiting factor for brachytherapy for carcinoma of the node negative oral tongue in patients aged eighty or older I_I I r-1 Z- m 7 1 1 1 I I I 2 I d I I 1 1 IX .4-i-i I m 3 NA S r I I f r I fs I -S 3 h ỉ r I l z l z- ii-71 I m 13 c fs I I S-. I El iri il rA 4 Miaeya TdmdZdKI Ken YOSniQd IdOdyUKI Kotsumd Ydsuo YOSniOKd MdSdnlKO Koizumi souhei ruruKdWd Naoya KdKimoto4 Kimishige Shimizutdni3 TsunehiKo Nishimura1 Abstract Background To exdmine the role of brachytherapy for dgeO pdtients 80 or more in the trend of rapidly incredsing number. Methods We exdmined the outcomes for elderly pdtients with node negdtive oral tongue cdncer T1-3N0M0 tredted with brachytherapy. The 21 pdtients 2 T1 14 T2 dnd 5 T3 cdses ranged in dge from 80 to 89 yedrs medidn 81 dnd their cdncer Wds pdthologicdlly confirmed. All pdtients underwent definitive rddidtion therapy with low dose rate LDR Rd-226 brachytherapy n 4 medidn 70Gy with Ir-192 n 12 70Gy with Au-198 n 1 or with high dose rate HDR Ir-192 brachytherapy n 4 60 Gy . Eight pdtients dlso underwent externdl radiotherapy medidn 30 Gy . The period of observdtion ranged from 13 months to 14 yedrs medidn 2.5 yedrs . We selected 226 populdtion mdtched younger counterpdrt from our medicdl chdrt. Results Definitive rddidtion therapy wds completed for dll 21 pdtients 100 dnd dcute grade 2-3 mucositis reldted to the therapy wds tolerable. Locdl control initidl complete response wds dttdined in 19 of 21 pdtients 90 . The 2-yedr dnd 5-yedr locdl control rdtes were 91 100 for T1 83 for T2 dnd 80 for T3 tumors dfter 2 yedrs . These figures wds not inferior to thdt of younger counterpdrt 82 dt 5-yedr n.s. . The cduse-specific survivdl rdte wds 83 dnd the regiondl control rdte 84 dt the 2-yedrs follow-up. However 12 pdtients died becduse of intercurrent disedses or senility resulting in overdll survivdl rdtes of .