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Báo cáo khoa học: "The in vivo study on the radiobiologic effect of prolonged delivery time to tumor control in C57BL mice implanted with Lewis lung cancer"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: The in vivo study on the radiobiologic effect of prolonged delivery time to tumor control in C57BL mice implanted with Lewis lung cancer. | Wang et al. Radiation Oncology 2011 6 4 http www.ro-journal.eom content 6 1 4 RADIATION ONCOLOGY RESEARCH Open Access The in vivo study on the radiobiologic effect of prolonged delivery time to tumor control in C57BL mice implanted with Lewis lung cancer 1 2 13 14 1 1 1 1 Xin Wang Xiao-Peng Xiong Jiade Lu Guo-Pei Zhu Shao-Qin He Chao-Su Hu Hong-Mei Ying Abstract Background High-precision radiation therapy techniques such as IMRT or sterotactic radiosurgery delivers more complex treatment fields than conventional techniques. The increased complexity causes longer dose delivery times for each fraction. The purpose of this work is to explore the radiobiologic effect of prolonged fraction delivery time on tumor response and survival in vivo. Methods 1-cm-diameter Lewis lung cancer tumors growing in the legs of C57BL mice were used. To evaluate effect of dose delivery prolongation 18 Gy was divided into different subfractions. 48 mice were randomized into 6 groups the normal control group the single fraction with 18 Gy group the two subfractions with 30 min interval group the seven subfractions with 5 min interval group the two subfractions with 60 min interval group and the seven subfractions with 10 min interval group. The tumor growth tendency the tumor growth delay and the mice survival time were analyzed. Results The tumor growth delay of groups with prolonged delivery time was shorter than the group with single fraction of 18 Gy P 0.05 . The tumor grow delay of groups with prolonged delivery time 30 min was longer than that of groups with prolonged delivery time 60 min P 0.05 . There was no significant difference between groups with same delivery time P 0.05 . Compared to the group with single fraction of 18 Gy the groups with prolonged delivery time shorten the mice survival time while there was no significant difference between the groups with prolonged delivery time 30 min and the groups with prolonged delivery time 60 min. Conclusions The prolonged delivery .