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Báo cáo khoa học: " Evaluation of early imaging response criteria in glioblastoma multiforme"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Evaluation of early imaging response criteria in glioblastoma multiforme. | Gladwish et al. Radiation Oncology 2011 6 121 http www.ro-journal.eom content 6 1 121 RADIATION ONCOLOGY RESEARCH Open Access Evaluation of early imaging response criteria in glioblastoma multiforme A z l s m I s z l X A Ỉ f 1 2 I c z c I z r A IX A 3 4Ý I I_I I r s lz2 6 f . I I z Z lzx A r i s Z 7 D z z A z z K I i I I - z2 7 1 ì i Cirr V i z z 1 6 Adam Giaowisn Eng-Siew KOh Jeremy nOiSdK Gina LOCKWOOO Barbara-Ann Millar warren Mason Eugene Yu8 Normand J Laperriere2 7 and Cynthia Ménard2 5 Abstract Background Early and accurate prediction of response to cancer treatment through imaging criteria is particularly important in rapidly progressive malignancies such as Glioblastoma Multiforme GBM . We sought to assess the predictive value of structural imaging response criteria one month after concurrent chemotherapy and radiotherapy RT in patients with GBM. Methods Thirty patients were enrolled from 2005 to 2007 median follow-up 22 months . Tumor volumes were delineated at the boundary of abnormal contrast enhancement on Tl-weighted images prior to and 1 month after RT. Clinical Progression CP occurred when clinical and or radiological events led to a change in chemotherapy management. Early Radiologic Progression ERP was defined as the qualitative interpretation of radiological progression one month post-RT. Patients with ERP were determined pseudoprogressors if clinically stable for 6 months. Receiver-operator characteristics were calculated for RECIST and MacDonald criteria along with alternative thresholds against 1 year CP-free survival and 2 year overall survival OS . Results 13 patients 52 were found to have ERP of whom 5 38.5 were pseudoprogressors. Patients with ERP had a lower median OS 11.2 mo than those without not reached p 0.001 . True progressors fared worse than pseudoprogressors median survival 7.2 mo vs. 19.0 mo p 0.001 . Volume thresholds performed slightly better compared to area and diameter thresholds in ROC analysis. Responses of 25 in volume or