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Báo cáo khoa học: " Oral Pirfenidone in patients with chronic fibrosis resulting from radiotherapy: a pilot study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " Oral Pirfenidone in patients with chronic fibrosis resulting from radiotherapy: a pilot study. | Radiation Oncology BioMed Central Open Access Oral Pirfenidone in patients with chronic fibrosis resulting from radiotherapy a pilot study Nicole L Simone 1 Benjamin P Soule2 Lynn Gerber3 Elizabeth Augustine3 Sharon Smith1 Rosemary M Altemus1 James B Mitchell2 and Kevin A Camphausen1 Address 1Radiation Oncology Branch National Cancer Institute National Institutes of Health 9000 Rockville Pike Building 10-CRC Room B2-3561 Bethesda Maryland 20892 USA 2Radiation Biology Branch National Cancer Institute National Institutes of Health 9000 Rockville Pike Building 10 Room B3B69 Bethesda Maryland 20892 USA and 3Center for Chronic Illness and Disability Department of Global and Community Health George Mason University Robinson B415B Mail Stop 5B7 4400 University Drive Fairfax Virginia 22030 USA Email Nicole L Simone - simonen@mail.nih.gov Benjamin P Soule - souleb@mail.nih.gov Lynn Gerber-ngerber1@gmu.edu Elizabeth Augustine - augustine_elizabeth@yahoo.com Sharon Smith - smiths@mail.nih.gov Rosemary M Altemus - raltemus@cox.net James B Mitchell - jbm@helix.nih.gov Kevin A Camphausen - camphauk@mail.nih.gov Corresponding author Published 31 May 2007 Received I March 2007 Radiation Oncology 2007 2 19 doi 10.1186 1748-717X-2-19 Accepted 3 1 May 2007 This article is available from http www.ro-journal.cOm content 2 1 19 2007 Simone et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Fibrosis is a common side effect after treatment with ionizing radiation. Several methods to ameliorate debilitating fibrosis have been employed but without consistent results. The goal of this pilot study is to determine if Pirfenidone a novel regulator of cytokine gene expression has the potential to ameliorate established .