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Báo cáo y học: "Biomarker profiles in serum and saliva of experimental Sjögren's syndrome: associations with specific autoimmune manifestations"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Biomarker profiles in serum and saliva of experimental Sjögren's syndrome: associations with specific autoimmune manifestations. | Available online http arthritis-research.eom content 10 1 R22 Open Access Research article Biomarker profiles in serum and saliva of experimental Sjogren s syndrome associations with specific autoimmune manifestations Nicolas Delaleu1 Heike Immervoll2 3 Janet Cornelius4 and Roland Jonsson1 5 6 1Broegelmann Research Laboratory The Gade Institute University of Bergen Haukelandsveien Bergen 5021 Norway 2Section of Pathology The Gade Institute University of Bergen Jonas Liesvei Bergen 5021 Norway 3Department of Pathology Haukeland University Hospital Jonas Liesvei Bergen 5021 Norway 4Department of Pathology Immunology and Laboratory Medicine University of Florida SW Archer Road Gainesville FL 32610 USA 5Department of Rheumatology Haukeland University Hospital Bergen Jonas Liesvei Bergen 5021 Norway 6Department of Otolaryngology Head and Neck Surgery Haukeland University Hospital Bergen Jonas Liesvei Bergen 5021 Norway Corresponding author Nicolas Delaleu nicolas.delaleu@gades.uib.no Received 28 Nov 2007 Revisions requested 8 Jan 2008 Revisions received 5 Feb 2008 Accepted 20 Feb 2008 Published 20 Feb 2008 Arthritis Research Therapy 2008 10 R22 doi 10.1186 ar2375 This article is online at http arthritis-research.com content 10 1 R22 2008 Delaleu et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Sjogren s syndrome SS is a systemic autoimmune disease that mainly targets the exocrine glands. The aim of this study was to investigate the involvement of 87 proteins measured in serum and 75 proteins analyzed in saliva in spontaneous experimental SS. In addition we intended to compute a model of the immunological situation representing the overt disease stage of SS. Methods Nondiabetic nonobese diabetic NOD .