Đang chuẩn bị liên kết để tải về tài liệu:
Báo cáo y học: "Systemic TNF blockade does not modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients – a prospective clinical study"

Không đóng trình duyệt đến khi xuất hiện nút TẢI XUỐNG

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Systemic TNF blockade does not modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients – a prospective clinical study. | Available online http arthritis-research.eom content 10 2 R33 Research article Systemic TNF blockade does not modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients - a prospective clinical study Erik Sundberg1 2 Cecilia Grundtman2 Erik af Klint2 Johan Lindberg3 Sofia Ernestam2 Ann-Kristin Ulfgren2 Helena Erlandsson Harris2 and Ulf Andersson1 Department of Woman and Child Health Pediatric Rheumatology Research Unit Karolinska Institutet Karolinska University Hospital Stockholm Sweden department of Medicine Rheumatology Unit Karolinska Institutet Karolinska University Hospital Stockholm Sweden department of Biotechnology AlbaNova University Center Royal Institute of Technology Stockholm Sweden Corresponding author Erik Sundberg erik.sundberg@ki.se Received 21 Nov 2007 Revisions requested 23 Jan 2008 Revisions received 26 Feb 2008 Accepted 17 Mar 2008 Published 17 Mar 2008 Arthritis Research Therapy 2008 10 R33 doi 10.1186 ar2387 This article is online at http arthritis-research.com content 10 2 R33 2008 Sundberg et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction High-mobility group box chromosomal protein 1 HMGB1 has recently been identified as an endogenous mediator of arthritis. TNF and IL-1P pivotal cytokines in arthritis pathogenesis both have the ability to induce the release of HMGB1 from myeloid and dendritic cells. It was therefore decided to investigate whether treatment based on TNF blockade in rheumatoid arthritis RA affects the expression of synovial HMGB1. Methods Repeated arthroscopy-guided sampling of synovial tissue was performed in nine patients with RA before and nine weeks after initiation of anti-TNF mAb infliximab .

TÀI LIỆU LIÊN QUAN

Báo cáo y học: "Most nuclear systemic autoantigens are extremely disordered proteins: implications for the etiology of systemic autoimmunity"

Báo cáo y học: " Epratuzumab targeting of CD22 affects adhesion molecule expression and migration of B-cells in systemic lupus erythematosus"

Báo cáo y học: "A GA microsatellite in the Fli1 promoter modulates gene expression and is associated with systemic lupus erythematosus patients without nephritis"

Báo cáo y học: " Increased prevalence of vulnerable atherosclerotic plaques and low levels of natural IgM antibodies against phosphorylcholine in patients with systemic lupus erythematosus"

Báo cáo y học: "Increased interleukin-23 receptor+ T cells in peripheral blood mononuclear cells of patients with systemic lupus erythematosu"

Báo cáo y học: "Response to: Comparison of laser Doppler imaging, fingertip lacticemy test, and nailfold capillaroscopy for assessment of digital microcirculation in systemic sclerosis - authors’ reply"

Báo cáo y học: "Steady-state mycophenolate mofetil pharmacokinetic parameters enable prediction of systemic lupus erythematosus clinical flares: an observational cohort study"

Báo cáo y học: "Disturbances of apoptotic cell clearance in systemic lupus erythematosus"

Báo cáo y học: "Anti-class a scavenger receptor autoantibodies from systemic lupus erythematosus patients impair phagocytic clearance of apoptotic cells by macrophages in vitro"

Báo cáo y học: "Follistatin-like protein 1 is elevated in systemic autoimmune diseases and correlated with disease activity in patients with rheumatoid arthritis."
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.